The Nuclear Option: Evidence Implicating the Cell Nucleus in Mechanotransduction.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of biomechanical engineering"
DOI: 10.1115/1.4035350
Abstract: Biophysical stimuli presented to cells via microenvironmental properties (e.g., alignment and stiffness) or external forces have a significant impact on cell function and behavior. Recently, the cell nucleus has been identified as a mechanosensitive organelle… read more here.
Keywords: cell nucleus; nuclear mechanotransduction; evidence; nucleus mechanotransduction ... See more keywords
Components and Mechanisms of Nuclear Mechanotransduction.
Sign Up to like & getrecommendations! Published in 2021 at "Annual review of cell and developmental biology"
DOI: 10.1146/annurev-cellbio-120319-030049
Abstract: The cell nucleus is best known as the container of the genome. Its envelope provides a barrier for passive macromolecule diffusion, which enhances the control of gene expression. As its largest and stiffest organelle, the… read more here.
Keywords: nuclear mechanotransduction; mechanisms nuclear; components mechanisms; biology ... See more keywords
LINCing Nuclear Mechanobiology With Skeletal Muscle Mass and Function
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.690577
Abstract: Skeletal muscle demonstrates a high degree of adaptability in response to changes in mechanical input. The phenotypic transformation in response to mechanical cues includes changes in muscle mass and force generating capabilities, yet the molecular… read more here.
Keywords: skeletal muscle; muscle; muscle mass; nuclear mechanotransduction ... See more keywords
FHODs: Nuclear tethered formins for nuclear mechanotransduction
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.1160219
Abstract: In this review, we discuss FHOD formins with a focus on recent studies that reveal a new role for them as critical links for nuclear mechanotransduction. The FHOD family in vertebrates comprises two structurally related… read more here.
Keywords: nuclear mechanotransduction; fhods nuclear; actin; tethered formins ... See more keywords
A Micropatterning Strategy to Study Nuclear Mechanotransduction in Cells
Sign Up to like & getrecommendations! Published in 2019 at "Micromachines"
DOI: 10.3390/mi10120810
Abstract: Micropatterning techniques have been widely used in biology, particularly in studies involving cell adhesion and proliferation on different substrates. Cell micropatterning approaches are also increasingly employed as in vitro tools to investigate intracellular mechanotransduction processes.… read more here.
Keywords: nuclear envelope; strategy study; nuclear mechanotransduction; mechanotransduction ... See more keywords