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   Articles with "nuclear periphery" as a keyword



Genome-Wide Identification of Chromatin Domains Anchored at the Nuclear Periphery in Plants.

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recommendations! Published in 2018 at "Methods in molecular biology"

DOI: 10.1007/978-1-4939-8657-6_23

Abstract: As a functional compartment, the nuclear periphery plays critical roles in regulating the spatial organization of chromatin in the nuclei and gene expression. Generally, the nuclear periphery is a transcriptionally repressed compartment enriched for silenced… read more here.

Keywords: genome wide; wide identification; chromatin; nuclear periphery ... See more keywords

Lamins Organize the Global Three-Dimensional Genome from the Nuclear Periphery.

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recommendations! Published in 2018 at "Molecular cell"

DOI: 10.1016/j.molcel.2018.05.017

Abstract: Lamins are structural components of the nuclear lamina (NL) that regulate genome organization and gene expression, but the mechanism remains unclear. Using Hi-C, we show that lamins maintain proper interactions among the topologically associated chromatin… read more here.

Keywords: nuclear periphery; chromatin domains; genome; lamins organize ... See more keywords

MyoD1 localization at the nuclear periphery is mediated by association of WFS1 with active enhancers

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recommendations! Published in 2025 at "Nature Communications"

DOI: 10.1038/s41467-025-57758-x

Abstract: Spatial organization of the mammalian genome influences gene expression and cell identity. While association of genes with the nuclear periphery is commonly linked to transcriptional repression, also active, expressed genes can localize at the nuclear… read more here.

Keywords: myod1 localization; active enhancers; periphery; nuclear periphery ... See more keywords

The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate

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recommendations! Published in 2025 at "Nature Cell Biology"

DOI: 10.1038/s41556-025-01703-z

Abstract: Heterochromatic loci marked by histone H3 lysine 9 dimethylation (H3K9me2) are enriched at the nuclear periphery in metazoans, but the effect of spatial position on heterochromatin function has not been defined. Here we remove three… read more here.

Keywords: marked genes; h3k9me2; nuclear periphery; cell ... See more keywords

Nuclear deformability depends on H3K9-methylated heterochromatin anchorage to the nuclear periphery in Caenorhabditis elegans

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recommendations! Published in 2025 at "Genetics"

DOI: 10.1093/genetics/iyaf086

Abstract: Abstract Nuclei adjust their deformability while migrating through constrictions to enable structural changes and maintain nuclear integrity. The effect of heterochromatin anchored at the nucleoplasmic face of the inner nuclear membrane on nuclear morphology and… read more here.

Keywords: deformability; nuclear migration; nuclear periphery; heterochromatin anchorage ... See more keywords

The fission yeast SUMO-targeted ubiquitin ligase Slx8 functionally associates with clustered centromeres and the silent mating-type region at the nuclear periphery

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recommendations! Published in 2024 at "Biology Open"

DOI: 10.1242/bio.061746

Abstract: The SUMO-targeted Ubiquitin ligase (STUbL) family is involved in multiple cellular processes via a wide range of mechanisms to maintain genome stability. One of the evolutionarily conserved functions of STUbL is to promote changes in… read more here.

Keywords: slx8; nuclear periphery; clustered centromeres; sumo ... See more keywords

Emerin interacts with histone methyltransferases to regulate repressive chromatin at the nuclear periphery

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recommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"

DOI: 10.3389/fcell.2022.1007120

Abstract: X-Linked Emery-Dreifuss muscular dystrophy is caused by mutations in the gene encoding emerin. Emerin is an inner nuclear membrane protein important for repressive chromatin organization at the nuclear periphery. Myogenic differentiation is a tightly regulated… read more here.

Keywords: nuclear periphery; repressive chromatin; emerin; ezh2 g9a ... See more keywords

GIP1 and GIP2 Contribute to the Maintenance of Genome Stability at the Nuclear Periphery

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recommendations! Published in 2021 at "Frontiers in Plant Science"

DOI: 10.3389/fpls.2021.804928

Abstract: The maintenance of genetic information is important in eukaryotes notably through mechanisms occurring at the nuclear periphery where inner nuclear membrane proteins and nuclear pore-associated components are key factors regulating the DNA damage response (DDR).… read more here.

Keywords: genome stability; nuclear periphery; periphery; gip1 gip2 ... See more keywords