Self-Organized Nuclear Positioning Synchronizes the Cell Cycle in Drosophila Embryos
Sign Up to like & getrecommendations! Published in 2019 at "Cell"
DOI: 10.1016/j.cell.2019.03.007
Abstract: The synchronous cleavage divisions of early embryogenesis require coordination of the cell-cycle oscillator, the dynamics of the cytoskeleton, and the cytoplasm. Yet, it remains unclear how spatially restricted biochemical signals are integrated with physical properties of… read more here.
Keywords: drosophila embryos; cell cycle; cycle; cycle drosophila ... See more keywords
Local Arrangement of Fibronectin by Myofibroblasts Governs Peripheral Nuclear Positioning in Muscle Cells
Sign Up to like & getrecommendations! Published in 2018 at "Developmental Cell"
DOI: 10.1016/j.devcel.2018.05.031
Abstract: Summary Skeletal muscle cells (myofibers) are rod-shaped multinucleated cells surrounded by an extracellular matrix (ECM) basal lamina. In contrast to other cell types, nuclei in myofibers are positioned just below the plasma membrane at the… read more here.
Keywords: peripheral nuclear; fibronectin; muscle cells; local arrangement ... See more keywords
ERK1/2 Phosphorylation of FHOD Connects Signaling and Nuclear Positioning Alternations in Cardiac Laminopathy.
Sign Up to like & getrecommendations! Published in 2019 at "Developmental cell"
DOI: 10.1016/j.devcel.2019.10.023
Abstract: Mutations in the lamin A/C gene (LMNA) cause cardiomyopathy and also disrupt nuclear positioning in fibroblasts. LMNA mutations causing cardiomyopathy elevate ERK1/2 activity in the heart, and inhibition of the ERK1/2 kinase activity ameliorates pathology,… read more here.
Keywords: positioning; phosphorylation fhod; activity; nuclear positioning ... See more keywords
Nuclear positioning facilitates amoeboid migration along the path of least resistance
Sign Up to like & getrecommendations! Published in 2019 at "Nature"
DOI: 10.1038/s41586-019-1087-5
Abstract: During metazoan development, immune surveillance and cancer dissemination, cells migrate in complex three-dimensional microenvironments1–3. These spaces are crowded by cells and extracellular matrix, generating mazes with differently sized gaps that are typically smaller than the… read more here.
Keywords: amoeboid migration; least resistance; path; path least ... See more keywords
Hierarchical integration of mitochondrial and nuclear positioning pathways by the Num1 EF hand.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular biology of the cell"
DOI: 10.1091/mbc.e21-12-0610-t
Abstract: Positioning organelles at the right place and time is critical for their function and inheritance. In budding yeast, mitochondrial and nuclear positioning require the anchoring of mitochondria and dynein to the cell cortex by clusters… read more here.
Keywords: inheritance; positioning pathways; mitochondrial nuclear; hierarchical integration ... See more keywords
ANGUSTIFOLIA Regulates Actin Filament Alignment for Nuclear Positioning in Leaves1[OPEN]
Sign Up to like & getrecommendations! Published in 2018 at "Plant Physiology"
DOI: 10.1104/pp.18.01150
Abstract: In dark-adapted Arabidopsis cells, nuclei position toward the body center of the leaf, a centripetal nuclear positioning process regulated by ANGUSTIFOLIA through the alignment of actin filaments. During dark adaptation, plant nuclei move centripetally toward… read more here.
Keywords: centripetal nuclear; alignment; dark; actin filaments ... See more keywords
Simulated Microgravity Reduces Focal Adhesions and Alters Cytoskeleton and Nuclear Positioning Leading to Enhanced Apoptosis via Suppressing FAK/RhoA-Mediated mTORC1/NF-κB and ERK1/2 Pathways
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms19071994
Abstract: Simulated-microgravity (SMG) promotes cell-apoptosis. We demonstrated that SMG inhibited cell proliferation/metastasis via FAK/RhoA-regulated mTORC1 pathway. Since mTORC1, NF-κB, and ERK1/2 signaling are important in cell apoptosis, we examined whether SMG-enhanced apoptosis is regulated via these… read more here.
Keywords: smg; fak rhoa; apoptosis; cell apoptosis ... See more keywords