Understanding renal nuclear protein accumulation: an in vitro approach to explain an in vivo phenomenon
Sign Up to like & getrecommendations! Published in 2017 at "Archives of Toxicology"
DOI: 10.1007/s00204-017-1970-5
Abstract: Proper subcellular trafficking is essential to prevent protein mislocalization and aggregation. Transport of the peroxisomal enzyme d-amino acid oxidase (DAAO) appears dysregulated by specific pharmaceuticals, e.g., the anti-overactive bladder drug propiverine or a norepinephrine/serotonin reuptake… read more here.
Keywords: protein; accumulation; vivo; understanding renal ... See more keywords
Nuclear G-protein-coupled receptors as putative novel pharmacological targets.
Sign Up to like & getrecommendations! Published in 2019 at "Drug discovery today"
DOI: 10.1016/j.drudis.2019.09.003
Abstract: Cell surface G-protein-coupled receptors (GPCRs) are targets for ˜30% of drugs currently on the market, and are the largest group of gene products targeted by drugs. Until recently, signaling mediated by GPCRs was thought to… read more here.
Keywords: novel pharmacological; protein coupled; pharmacological targets; coupled receptors ... See more keywords
Targeting nuclear protein TDP-43 by cell division cycle kinase 7 inhibitors: A new therapeutic approach for amyotrophic lateral sclerosis.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112968
Abstract: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with no known cure. Aggregates of the nuclear protein TDP-43 have been recognized as a hallmark of proteinopathy in both familial and sporadic cases of ALS.… read more here.
Keywords: protein tdp; tdp; amyotrophic lateral; cell division ... See more keywords
Inner nuclear protein Matrin-3 coordinates cell differentiation by stabilizing chromatin architecture
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-26574-4
Abstract: Precise control of gene expression during differentiation relies on the interplay of chromatin and nuclear structure. Despite an established contribution of nuclear membrane proteins to developmental gene regulation, little is known regarding the role of… read more here.
Keywords: protein; cell differentiation; differentiation; inner nuclear ... See more keywords
The first set of universal nuclear protein-coding loci markers for avian phylogenetic and population genetic studies
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-33646-x
Abstract: Multiple nuclear markers provide genetic polymorphism data for molecular systematics and population genetic studies. They are especially required for the coalescent-based analyses that can be used to accurately estimate species trees and infer population demographic… read more here.
Keywords: coding loci; population genetic; protein coding; population ... See more keywords
A nuclear protein, PfMORC confers melatonin dependent synchrony of the human malaria parasite P. falciparum in the asexual stage
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-81235-2
Abstract: The host hormone melatonin is known to modulate the asexual cell-cycle of the human malaria parasite Plasmodium falciparum and the kinase PfPK7 is fundamental in the downstream signaling pathways. The nuclear protein PfMORC displays a… read more here.
Keywords: melatonin; parasite; protein pfmorc; nuclear protein ... See more keywords
Nuclear protein in testis carcinoma: a diagnostic and therapeutic challenge
Sign Up to like & getrecommendations! Published in 2021 at "Internal Medicine Journal"
DOI: 10.1111/imj.15414
Abstract: Nuclear protein in testis (NUT) carcinoma, formerly known as NUT midline carcinoma, is a rare but aggressive cancer. The exact prevalence is unknown, but median prognosis is approximately 6 months in the reported cases. NUT… read more here.
Keywords: nut carcinoma; carcinoma; disease; nuclear protein ... See more keywords
Proteomic study revealed antipsychotics-induced nuclear protein regulations in B35 cells are similar to the regulations in C6 cells and rat cortex
Sign Up to like & getrecommendations! Published in 2018 at "BMC Pharmacology & Toxicology"
DOI: 10.1186/s40360-018-0199-0
Abstract: BackgroundBased on accumulating evidence, the regulation of protein expression by antipsychotic drugs (APDs) might be closely related to the control of psychotic symptoms when these drugs are used to treat mental disorders. The low quantity… read more here.
Keywords: protein; protein expression; b35 cells; rat cortex ... See more keywords
Vimentin-positive and Alpha-fetoprotein-elevated Nuclear Protein of the Testis Midline Carcinoma: A Case Report and Review of the Literature.
Sign Up to like & getrecommendations! Published in 2021 at "Internal medicine"
DOI: 10.2169/internalmedicine.7019-21
Abstract: Nuclear protein of the testis (NUT) midline carcinoma (NMC) is a rare malignant tumor expressing NUT with BRD4/3 rearrangements and is sometimes misdiagnosed as germinoma, especially in alpha-fetoprotein (AFP)-elevated cases. A 28-year-old man had a… read more here.
Keywords: protein testis; midline carcinoma; nuclear protein; vimentin positive ... See more keywords
Enhanced Synthesis of Foreign Nuclear Protein Stimulates Viral Reproduction via the Induction of γ-Thionin Expression
Sign Up to like & getrecommendations! Published in 2022 at "Plants"
DOI: 10.3390/plants11121530
Abstract: Plants are a promising platform for recombinant protein production. Here we propose a novel approach to increase the level of viral vector-mediated recombinant protein synthesis. This approach is based on the hypothesis that antiviral protection… read more here.
Keywords: thionin; expression; foreign nuclear; nuclear protein ... See more keywords
Downregulation of tumor protein 53-inducible nuclear protein 1 expression in hepatocellular carcinoma correlates with poor prognosis
Sign Up to like & getrecommendations! Published in 2017 at "Oncology Letters"
DOI: 10.3892/ol.2016.5537
Abstract: The expression of tumor protein 53-inducible nuclear protein 1 (TP53INP1) is upregulated in certain cancers and downregulated in others. However, its expression in hepatocellular carcinoma (HCC) is not clear. The present study aimed to investigate… read more here.
Keywords: protein; protein inducible; inducible nuclear; tumor protein ... See more keywords