Functional analysis of nuclear receptor HR96 gene in Bombyx mori exposed to phoxim.
Sign Up to like & getrecommendations! Published in 2022 at "Archives of insect biochemistry and physiology"
DOI: 10.1002/arch.21910
Abstract: The nuclear receptor (NRs) gene family functions as ligand-dependent transcription factors in a variety of animals, which participates in a variety of biological processes, such as cell differentiation, metabolic regulation, reproduction, development, insect metamorphosis. In… read more here.
Keywords: hr96 gene; bmhr96; gene; nuclear receptor ... See more keywords
NSD3, a member of nuclear receptor‐binding SET domain family, is a potential prognostic biomarker for pancreatic cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Medicine"
DOI: 10.1002/cam4.5774
Abstract: Members of the nuclear receptor‐binding SET domain (NSD) family of histone H3 lysine 36 methyltransferases comprise NSD1, NSD2 (MMSET/WHSC1), and NSD3 (Wolf–Hirschhorn syndrome candidate 1‐like 1, WHSC1L1). While the expression of NSD genes is essential… read more here.
Keywords: receptor binding; set domain; nuclear receptor; cancer ... See more keywords
Adult functions for the Drosophila DHR78 nuclear receptor
Sign Up to like & getrecommendations! Published in 2018 at "Developmental Dynamics"
DOI: 10.1002/dvdy.24608
Abstract: Background: The Testicular Receptors 2 and 4 (TR2, TR4) comprise a small subfamily of orphan nuclear receptors. Genetic studies in mouse models have identified roles for TR4 in developmental progression, fertility, brain development, and metabolism,… read more here.
Keywords: drosophila dhr78; adult functions; nuclear receptor; dhr78 nuclear ... See more keywords
Muscle‐restricted nuclear receptor interaction protein knockout causes motor neuron degeneration through down‐regulation of myogenin at the neuromuscular junction
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.12299
Abstract: Nuclear receptor interaction protein (NRIP) is a calcium/calmodulin (CaM) binding protein. Nuclear receptor interaction protein interacts with CaM to activate calcineurin and CaMKII signalling. The conventional NRIP knockout mice (global knockout) showed muscular abnormality with… read more here.
Keywords: interaction protein; receptor interaction; nuclear receptor;
Nuclear receptor 4A1 (NR4A1) antagonists target paraspeckle component 1 (PSPC1) in cancer cells.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular carcinogenesis"
DOI: 10.1002/mc.23362
Abstract: Paraspeckles compound 1 (PSPC1) is a multifunctional protein that plays an important role in cancer cells, where PSPC1 is a master regulator of pro-oncogenic responses that includes activation of TGFβ (TGFβ1), TGFβ-dependent EMT, and metastasis. The… read more here.
Keywords: receptor 4a1; nr4a1 antagonists; nuclear receptor; pspc1 ... See more keywords
The nuclear receptor superfamily: A structural perspective
Sign Up to like & getrecommendations! Published in 2018 at "Protein Science"
DOI: 10.1002/pro.3496
Abstract: Nuclear receptors (NRs) are a family of transcription factors that regulate numerous physiological processes such as metabolism, reproduction, inflammation, as well as the circadian rhythm. NRs sense changes in lipid metabolite levels to drive differential… read more here.
Keywords: superfamily structural; receptor superfamily; physiology; nuclear receptor ... See more keywords
Isolation and Purification of Tissue Resident Macrophages for the Analysis of Nuclear Receptor Activity.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9130-3_5
Abstract: Tissue resident macrophages (TRMs) are multifunctional immune cells present in all tissues, contributing to the correct development, homeostasis, and protection against pathogens and injury. TRMs are morphologically and functionally heterogeneous, as a result of both… read more here.
Keywords: tissue resident; tissue; nuclear receptor; receptor activity ... See more keywords
Nuclear Receptor NR5A2 Promotes Neuronal Identity in the Adult Hippocampus.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular neurobiology"
DOI: 10.1007/s12035-020-02222-8
Abstract: Neurogenesis in the dentate gyrus (DG) of the adult hippocampus is actively involved in brain homeostasis. Thus, identification of novel regulators in adult neurogenesis could significantly contribute to new therapies. We have recently unraveled the… read more here.
Keywords: adult; neurogenesis; neuronal identity; nuclear receptor ... See more keywords
Sirtuin 7-dependent deacetylation of DDB1 regulates the expression of nuclear receptor TR4.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.06.057
Abstract: Sirtuin 7 (SIRT7) is an NAD+-dependent deacetylase/deacylase, but only a limited number of SIRT7 substrates have been identified. Recently, we found that Sirt7 knockout mice are resistant to high-fat diet-induced fatty liver, and that SIRT7… read more here.
Keywords: ddb1; deacetylation; tr4; nuclear receptor ... See more keywords
Discovery of atorvastatin as a tetramer stabilizer of nuclear receptor RXRα through structure-based virtual screening.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.01.007
Abstract: Retinoid X receptor alpha (RXRα), a central member of the nuclear receptor superfamily and a key regulator of many signal transduction pathways, has been an attractive drug target. We previously discovered that an N-terminally truncated… read more here.
Keywords: tetramer stabilizer; screening; atorvastatin; nuclear receptor ... See more keywords
Protective effects of a herbal extract combination of Bupleurum falcatum, Paeonia suffruticosa, and Angelica dahurica against MPTP-induced neurotoxicity via regulation of nuclear receptor-related 1 protein
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2016.10.029
Abstract: Parkinson's disease (PD) is one of the progressive neurodegenerative diseases of whose condition is characterized by dopaminergic neuronal cell loss and dysfunction in the substantia nigra pars compacta (SNpc) and the striatum. Recent studies have… read more here.
Keywords: receptor related; mptp induced; nuclear receptor; related protein ... See more keywords