The DUX4 protein is a co‐repressor of the progesterone and glucocorticoid nuclear receptors
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14416
Abstract: DUX4 is a transcription factor required during early embryonic development in placental mammals. In this work, we provide evidence that DUX4 is a co‐repressor of nuclear receptors (NRs) of progesterone (PR) and glucocorticoids (GR). The… read more here.
Keywords: repressor; progesterone; nuclear receptors; dux4 protein ... See more keywords
Integrated in silico and in vivo approaches to investigate effects of BDE-99 mediated by the nuclear receptors on developing zebrafish.
Sign Up to like & getrecommendations! Published in 2018 at "Environmental toxicology and chemistry"
DOI: 10.1002/etc.4000
Abstract: One of the most abundant polybrominated diphenyl ethers (PBDEs) is 2,2',4,4',5-pentabromodiphenyl ether (BDE-99), which persists and potentially bioaccumulates in aquatic wildlife. Previous studies in mammals have shown that BDE-99 affects development and disrupts certain endocrine… read more here.
Keywords: nuclear receptors; silico vivo; receptor; mediated nuclear ... See more keywords
Is This the Time to Reconsider the Names for Xenobiotic Nuclear Receptors?
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.30218
Abstract: Pregnane X receptor (PXR) has been known as a xenobiotic nuclear receptor and transcriptional factor that is important for inducing the expression of genes involved in drug disposition (1, 2). Recently, PXR has emerged to… read more here.
Keywords: time reconsider; nuclear receptors; names xenobiotic; xenobiotic nuclear ... See more keywords
Potential roles of nuclear receptors in mediating neurodevelopmental toxicity of known endocrine‐disrupting chemicals in ascidian embryos
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Reproduction and Development"
DOI: 10.1002/mrd.23219
Abstract: Endocrine Disrupting Chemicals (EDCs) are molecules able to interfere with the vertebrate hormonal system in different ways, a major one being the modification of the activity of nuclear receptors (NRs). Several NRs are expressed in… read more here.
Keywords: nuclear receptors; endocrine disrupting; potential roles; roles nuclear ... See more keywords
Nuclear Receptors
Sign Up to like & getrecommendations! Published in 2019 at "Therapie"
DOI: 10.1007/978-1-4939-9195-2
Abstract: Nuclear receptors form a superfamily of transcriptional regulators including both classical hormone receptors and orphan receptors. The functional anatomy of the receptors is described as well as their interaction with coactivators, cointegrators and corepressors. Nuclear… read more here.
Keywords: nuclear receptors;
Effect of ApoA4 on SERPINA3 mediated by nuclear receptors NR4A1 and NR1D1 in hepatocytes.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.04.058
Abstract: ApoA4 exerts anti-inflammatory effects, but the mechanism remains unclear. SERPINA3 is a member of the serine proteinase inhibitor gene family, and has been shown to be involved in anti-inflammation and associated with a number of… read more here.
Keywords: nuclear receptors; serpina3; effect apoa4; receptors nr4a1 ... See more keywords
Altered Gene expression of ABC transporters, nuclear receptors and oxidative stress signaling in zebrafish embryos exposed to CdTe quantum dots.
Sign Up to like & getrecommendations! Published in 2019 at "Environmental pollution"
DOI: 10.1016/j.envpol.2018.10.092
Abstract: Adenosine triphosphate-binding cassette (ABC) transporters, including P-glycoprotein (Pgp) and multi-resistance associated proteins (Mrps), have been considered important participants in the self-protection of zebrafish embryos against environmental pollutants, but their possible involvement in the efflux and… read more here.
Keywords: abc transporters; nuclear receptors; receptors oxidative; zebrafish embryos ... See more keywords
Type II nuclear receptors with potential role in Alzheimer disease.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular aspects of medicine"
DOI: 10.1016/j.mam.2020.100940
Abstract: Nuclear receptors are ligand-activated transcription factors that can modulated cellular processes involved in the development, homeostasis, cell proliferation, metabolism, and reproduction through the control of the specific genetic and molecular program. In the central nervous… read more here.
Keywords: receptors potential; nuclear receptors; alzheimer disease; role alzheimer ... See more keywords
Allosteric small molecule modulators of nuclear receptors
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2019.01.022
Abstract: Nuclear Receptors (NRs) are multi-domain proteins, whose natural regulation occurs via ligands for a classical, orthosteric, binding pocket and via intra- and inter-domain allosteric mechanisms. Allosteric modulation of NRs via synthetic small molecules has recently… read more here.
Keywords: nuclear receptors; small molecule; small molecules; molecule modulators ... See more keywords
Profiling of bisphenol A and eight its analogues on transcriptional activity via human nuclear receptors.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology"
DOI: 10.1016/j.tox.2018.12.001
Abstract: Several bisphenol A (BPA) analogues have been detected in environmental samples, foodstuffs, and/or human biological samples, and there is concern regarding their potential endocrine-disrupting effects. In this study, we characterized the agonistic and/or antagonistic activities… read more here.
Keywords: nuclear receptors; eight analogues; via human; human nuclear ... See more keywords
Response of the nuclear receptors PXR and CAR and their target gene mRNA expression in female piglets exposed to zearalenone
Sign Up to like & getrecommendations! Published in 2018 at "Toxicon"
DOI: 10.1016/j.toxicon.2018.06.081
Abstract: ABSTRACT A study was conducted to determine the effects of zearalenone (ZEN) on the mRNA expression of pregnane X receptor (PXR), constitutive and rostane receptor (CAR), and phase I and II enzymes as well as… read more here.
Keywords: nuclear receptors; pxr car; female piglets; expression ... See more keywords