Modulation of nuclear REST by alternative splicing: a potential therapeutic target for Huntington's disease
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DOI: 10.1111/jcmm.13209
Abstract: Huntington's disease (HD) is caused by a genetically mutated huntingtin (mHtt) protein with expanded polyQ stretch, which impairs cytosolic sequestration of the repressor element‐1 silencing transcription factor (REST), resulting in excessive nuclear REST and subsequent… read more here.
Keywords: modulation nuclear; nuclear rest; huntington disease; rest ... See more keywords