Analysis of Tertiary Interactions between SART3 and U6 Small Nuclear RNA Using Modified Nanocapillaries.
Sign Up to like & getrecommendations! Published in 2017 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.6b04245
Abstract: We employed modified glass nanocapillaries to investigate interactions between the RNA-binding protein, known as cell carcinoma antigen recognized by T cells-3 (SART3), and the noncoding spliceosome component, U6 small nuclear RNA (snRNA), at the single-molecule… read more here.
Keywords: analysis tertiary; small nuclear; nuclear rna; modified nanocapillaries ... See more keywords
Controlling nuclear RNA levels
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Genetics"
DOI: 10.1038/s41576-018-0013-2
Abstract: RNA turnover is an integral part of cellular RNA homeostasis and gene expression regulation. Whereas the cytoplasmic control of protein-coding mRNA is often the focus of study, we discuss here the less appreciated role of… read more here.
Keywords: nuclear rna; rna; controlling nuclear; rna decay ... See more keywords
The splicing factor SRSF3 is functionally connected to the nuclear RNA exosome for intronless mRNA decay
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-31078-1
Abstract: The RNA exosome fulfills important functions in the processing and degradation of numerous RNAs species. However, the mechanisms of recruitment to its various nuclear substrates are poorly understood. Using Epstein-Barr virus mRNAs as a model,… read more here.
Keywords: rna exosome; nuclear rna; splicing factor; mrna decay ... See more keywords
Out or decay: fate determination of nuclear RNAs.
Sign Up to like & getrecommendations! Published in 2020 at "Essays in biochemistry"
DOI: 10.1042/ebc20200005
Abstract: In eukaryotes, RNAs newly synthesized by RNA polymerase II (RNAPII) undergo several processing steps prior to transport to the cytoplasm. It has long been known that RNAs with defects in processing or export are removed… read more here.
Keywords: rnas; fate; fate determination; nuclear rna ... See more keywords
Differential nuclear import regulates nuclear RNA inheritance following mitosis
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e23-01-0004
Abstract: Mitosis results in a dramatic reorganization of chromatin structure to promote chromosome compaction and segregation to daughter cells. Consequently, mitotic entry is accompanied by transcriptional silencing and removal of most chromatin-bound RNA from chromosomes. As… read more here.
Keywords: mitosis; following mitosis; chromatin; rna inheritance ... See more keywords
Surveillance-ready transcription: nuclear RNA decay as a default fate
Sign Up to like & getrecommendations! Published in 2018 at "Open Biology"
DOI: 10.1098/rsob.170270
Abstract: Eukaryotic cells synthesize enormous quantities of RNA from diverse classes, most of which are subject to extensive processing. These processes are inherently error-prone, and cells have evolved robust quality control mechanisms to selectively remove aberrant… read more here.
Keywords: default fate; transcription; surveillance; nuclear rna ... See more keywords
Evidence for Viral mRNA Export from Ebola Virus Inclusion Bodies by the Nuclear RNA Export Factor NXF1
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.00900-22
Abstract: Filoviruses such as the Ebola virus (EBOV) cause severe hemorrhagic fevers with high case fatality rates and limited treatment options. The identification of virus-host cell interactions shared among several viruses would represent promising targets for… read more here.
Keywords: viral mrna; ebola virus; inclusion bodies; export ... See more keywords
RNA-binding protein Mub1 and the nuclear RNA exosome act to fine-tune environmental stress response
Sign Up to like & getrecommendations! Published in 2021 at "Life Science Alliance"
DOI: 10.26508/lsa.202101111
Abstract: Comparative RNA interactome capture identifies potential regulators of RNA metabolism in fission yeast and reveals RNA exosome–dependent buffering of stress-responsive gene expression networks. The nuclear RNA exosome plays a key role in controlling the levels… read more here.
Keywords: exosome; rna binding; stress; nuclear rna ... See more keywords
Nuclear RNA Exosome and Pervasive Transcription: Dual Sculptors of Genome Function
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms222413401
Abstract: The genome is pervasively transcribed across various species, yielding numerous non-coding RNAs. As a counterbalance for pervasive transcription, various organisms have a nuclear RNA exosome complex, whose structure is well conserved between yeast and mammalian… read more here.
Keywords: exosome pervasive; nuclear rna; pervasive transcription; rna exosome ... See more keywords