Investigating cardiac β-adrenergic nuclear signaling with FRET-based biosensors.
Sign Up to like & getrecommendations! Published in 2020 at "Annales d'endocrinologie"
DOI: 10.1016/j.ando.2020.04.001
Abstract: By activating membrane β-adrenergic receptors (β-AR), noradrenaline and adrenaline are the most powerful stimulators of cardiac function. β-ARs are coupled to the synthesis of cAMP, which activates the cAMP-dependent protein kinase (PKA). PKA regulates the… read more here.
Keywords: activation; cardiac adrenergic; nuclear signaling; adrenergic nuclear ... See more keywords
Mitophagy initiates retrograde mitochondrial-nuclear signaling to guide retinal pigment cell heterogeneity
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2109286
Abstract: ABSTRACT Age-related macular degeneration (AMD), the leading cause of blindness among the elderly, is without treatment for early disease. Degenerative retinal pigment epithelial (RPE) cell heterogeneity is a well-recognized but understudied pathogenic factor. Due to… read more here.
Keywords: rpe; retrograde mitochondrial; retinal pigment; mitochondrial nuclear ... See more keywords
The emerging role of estrogen's non-nuclear signaling in the cardiovascular disease
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2023.1127340
Abstract: Sexual dimorphism exists in the epidemiology of cardiovascular disease (CVD), which indicates the involvement of sexual hormones in the pathophysiology of CVD. In particular, ample evidence has demonstrated estrogen's protective effect on the cardiovascular system.… read more here.
Keywords: estrogen; cardiovascular disease; role; non nuclear ... See more keywords
TF-ChIP Method for Tissue-Specific Gene Targets
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2019.00095
Abstract: Chromatin immunoprecipitation (ChIP) is an assay developed in order to define the dynamic nature of transcription processes. This method has been widely employed to identify methylated and acetylated DNA sequences in a variety of organs… read more here.
Keywords: tissue specific; nuclear signaling; method; tissue ... See more keywords