Tau aggregates are RNA-protein assemblies that mislocalize multiple nuclear speckle components
Sign Up to like & getrecommendations! Published in 2021 at "Neuron"
DOI: 10.1016/j.neuron.2021.03.026
Abstract: Tau aggregates contribute to neurodegenerative diseases, including frontotemporal dementia and Alzheimer's disease (AD). Although RNA promotes tau aggregation in vitro, whether tau aggregates in cells contain RNA is unknown. We demonstrate, in cell culture and mouse… read more here.
Keywords: tau; nuclear speckle; tau aggregates; aggregates rna ... See more keywords
USP42 drives nuclear speckle mRNA splicing via directing dynamic phase separation to promote tumorigenesis
Sign Up to like & getrecommendations! Published in 2021 at "Cell Death and Differentiation"
DOI: 10.1038/s41418-021-00763-6
Abstract: Liquid–liquid phase separation is considered a generic approach to organize membrane-less compartments, enabling the dynamic regulation of phase-separated assemblies to be investigated and pivotal roles of protein posttranslational modifications to be demonstrated. By surveying the… read more here.
Keywords: phase separation; nuclear speckle; mrna splicing; separation ... See more keywords
Nuclear speckle integrity and function require TAO2 kinase
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2206046119
Abstract: Significance In these studies, TAO2 kinase has been revealed as a constituent and key player in nuclear speckle structure and function, including RNA splicing and nuclear export. These findings add knowledge to the cell biology… read more here.
Keywords: speckle integrity; tao2 kinase; integrity function; nuclear speckle ... See more keywords
Four-dimensional nuclear speckle phase separation dynamics regulate proteostasis
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DOI: 10.1126/sciadv.abl4150
Abstract: A cell-autonomous 12-hour clock coordinates nuclear speckle LLPS with proteostasis control. read more here.
Keywords: speckle phase; nuclear speckle; four dimensional; dimensional nuclear ... See more keywords
Nuclear speckle fusion via long-range directional motion regulates speckle morphology after transcriptional inhibition
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cell Science"
DOI: 10.1242/jcs.226563
Abstract: ABSTRACT Although the formation of RNA-protein bodies has been studied intensively, their mobility and how their number and size are regulated are still poorly understood. Here, we show significantly increased mobility of nuclear speckles after… read more here.
Keywords: nuclear speckle; speckle; long range; transcriptional inhibition ... See more keywords