Speculating on the Roles of Nuclear Speckles: How RNA‐Protein Nuclear Assemblies Affect Gene Expression
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DOI: 10.1002/bies.202000104
Abstract: Nuclear speckles are eukaryotic nuclear bodies enriched in splicing factors. Their exact purpose has been a matter of debate. The different proposed roles of nuclear speckles are reviewed and an additional layer of function is… read more here.
Keywords: nuclear speckles; splicing factors; gene expression; roles nuclear ... See more keywords
p53 mediates target gene association with nuclear speckles for amplified RNA expression.
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DOI: 10.1016/j.molcel.2021.03.006
Abstract: Nuclear speckles are prominent nuclear bodies that contain proteins and RNA involved in gene expression. Although links between nuclear speckles and gene activation are emerging, the mechanisms regulating association of genes with speckles are unclear.… read more here.
Keywords: nuclear speckles; speckle association; association; expression ... See more keywords
USP42 enhances homologous recombination repair by promoting R-loop resolution with a DNA–RNA helicase DHX9
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DOI: 10.1038/s41389-020-00244-4
Abstract: The nucleus of mammalian cells is compartmentalized by nuclear bodies such as nuclear speckles, however, involvement of nuclear bodies, especially nuclear speckles, in DNA repair has not been actively investigated. Here, our focused screen for… read more here.
Keywords: nuclear speckles; dsb; homologous recombination; rna helicase ... See more keywords
Inhibition of mitochondrial complex III or dihydroorotate dehydrogenase (DHODH) triggers formation of poly(A)+ RNA foci adjacent to nuclear speckles following activation of ATM (ataxia telangiectasia mutated)
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DOI: 10.1080/15476286.2022.2146919
Abstract: ABSTRACT Intracellular and intercellular signalling networks play an essential role in optimizing cellular homoeostasis and are thought to be partly reflected in nuclear mRNA dynamics. However, the regulation of nuclear mRNA dynamics by intracellular and… read more here.
Keywords: rna; nuclear speckles; poly rna; complex iii ... See more keywords
Mammalian nuclear speckles exhibit stable association with chromatin: a biochemical study
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DOI: 10.1080/19491034.2021.2024948
Abstract: ABSTRACT Nuclear Speckles (NS) are phase-separated condensates of protein and RNA whose components dynamically coordinate RNA transcription, splicing, transport and DNA repair. NS, probed largely by imaging studies, remained historically well known as Interchromatin Granule… read more here.
Keywords: association chromatin; nuclear speckles; exhibit stable; chromatin ... See more keywords
ZFC3H1 prevents RNA trafficking into nuclear speckles through condensation
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DOI: 10.1093/nar/gkab774
Abstract: Abstract Controlling proper RNA pool for nuclear export is important for accurate gene expression. ZFC3H1 is a key controller that not only facilitates nuclear exosomal degradation, but also retains its bound polyadenylated RNAs in the… read more here.
Keywords: nuclear speckles; degradation; condensation; rna trafficking ... See more keywords
ZFC3H1 and U1-70K promote the nuclear retention of mRNAs with 5′ splice site motifs within nuclear speckles
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DOI: 10.1261/rna.079104.122
Abstract: Quality control of mRNA represents an important regulatory mechanism for gene expression in eukaryotes. One component of this quality control is the nuclear retention and decay of misprocessed RNAs. Previously, we demonstrated that mature mRNAs… read more here.
Keywords: retention; nuclear retention; nuclear speckles; retention mrnas ... See more keywords
G-Quadruplex Structures Colocalize with Transcription Factories and Nuclear Speckles Surrounded by Acetylated and Dimethylated Histones H3
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DOI: 10.3390/ijms22041995
Abstract: G-quadruplexes (G4s) are four-stranded helical structures that regulate several nuclear processes, including gene expression and telomere maintenance. We observed that G4s are located in GC-rich (euchromatin) regions and outside the fibrillarin-positive compartment of nucleoli. Genomic… read more here.
Keywords: nuclear speckles; quadruplex structures; structures colocalize; transcription factories ... See more keywords