Nuclear accumulation of symplekin promotes cellular proliferation and dedifferentiation in an ERK1/2-dependent manner
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DOI: 10.1038/s41598-017-04005-z
Abstract: Symplekin is a multifunctional protein that localizes to both tight junctions and the nucleus in polarized epithelial cells, with confirmed roles in mRNA maturation, transcriptional modulation and tight-junction assembly. However, the mechanisms governing its subcellular… read more here.
Keywords: symplekin; accumulation; nuclear symplekin; proliferation dedifferentiation ... See more keywords