Favorable tumor uptake and nuclear transport of Auger electrons by nuclear targeting with 111In-trastuzumab in an intraperitoneal tumor mouse model
Sign Up to like & getrecommendations! Published in 2022 at "Nuclear Medicine Communications"
DOI: 10.1097/mnm.0000000000001571
Abstract: Objectives The 111In-labeled anti-HER2 antibody trastuzumab modified with a nuclear-localizing sequence (NLS) peptide (111In-trastuzumab-NLS) is a radiopharmaceutical candidate for Auger electron radioimmunotherapy (AE-RIT). However, in-vivo action of 111In-trastuzumab-NLS is poorly understood in intraperitoneal tumors. We… read more here.
Keywords: trastuzumab nls; nuclear targeting; 111in trastuzumab; tumor ... See more keywords
Phosphatase 1 Nuclear Targeting Subunit, a Novel DNA Repair Partner of PARP1.
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DOI: 10.1158/0008-5472.can-19-0798
Abstract: There is extensive literature on PARP1, owing to the multiple functions of PARP1 for DNA repair, aging, chromatin remodeling and transcription, and to the successful clinical development of four PARP inhibitors. In this issue of… read more here.
Keywords: dna repair; nuclear targeting; targeting subunit; phosphatase nuclear ... See more keywords
Phosphatase 1 Nuclear Targeting Subunit (PNUTS) Regulates Aurora Kinases and Mitotic Progression
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DOI: 10.1158/1541-7786.mcr-17-0670
Abstract: Mitotic progression is regulated largely by reversible phosphorylation events that are mediated by mitotic kinases and phosphatases. Protein phosphatase 1 (PP1) has been shown to play a crucial role in regulation of mitotic entry, progression,… read more here.
Keywords: phosphatase nuclear; nuclear targeting; aurora kinases; mitotic progression ... See more keywords