Naringenin facilitates M2 macrophage polarization after myocardial ischemia–reperfusion by promoting nuclear translocation of transcription factor EB and inhibiting the NLRP3 inflammasome pathway
Sign Up to like & getrecommendations! Published in 2023 at "Environmental Toxicology"
DOI: 10.1002/tox.23774
Abstract: Myocardial ischemia–reperfusion injury (MIRI) remains an unsolved puzzle in medical circles. Naringenin (NAR) is a flavonoid with cardioprotective potential. The purpose of this article was to discuss the protective mechanism of NAR in MIRI by… read more here.
Keywords: macrophage polarization; inflammasome pathway; nuclear translocation; polarization ... See more keywords
Significance of AHR nuclear translocation sequence in 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced cPLA2α activation and hydronephrosis
Sign Up to like & getrecommendations! Published in 2019 at "Archives of Toxicology"
DOI: 10.1007/s00204-019-02414-9
Abstract: The aryl hydrocarbon receptor (AHR) plays a major role in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced toxicity phenotypes. TCDD bound to AHR elicits both genomic action in which target genes are transcriptionally upregulated and nongenomic action in which cytosolic phospholipase… read more here.
Keywords: tcdd; tetrachlorodibenzo dioxin; activation; hydronephrosis ... See more keywords
7-Hydorxyindirubin is capable of specifically inhibiting anticancer drug-induced YB-1 nuclear translocation without showing cytotoxicity in HepG2 hepatocellular carcinoma cells.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.01.048
Abstract: Hepatocellular carcinoma (HCC) is one of the most common human malignant tumors. It is known that in the cells of many cancers, including HCC, nuclear translocation and accumulation of YB-1 often indicates a poor prognosis.… read more here.
Keywords: translocation without; drug; induced nuclear; translocation ... See more keywords
A tumoural angiogenic gateway blocker, Benzophenone‐1B represses the HIF‐1&agr; nuclear translocation and its target gene activation against neoplastic progression
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2016.11.009
Abstract: Graphical abstract Figure. No Caption available. ABSTRACT Hypoxia is an important module in all solid tumours to promote angiogenesis, invasion and metastasis. Stabilization and subsequent nuclear localization of HIF‐1&agr; subunits result in the activation of… read more here.
Keywords: hif; target; nuclear translocation; hif agr ... See more keywords
Cedrol suppresses glioblastoma progression by triggering DNA damage and blocking nuclear translocation of the androgen receptor.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer letters"
DOI: 10.1016/j.canlet.2020.09.007
Abstract: Glioblastoma (GBM) is the most common and aggressive primary brain tumor with great invasiveness and resistance to chemotherapy, which presents a treatment challenge. In this study, we investigated the antitumor effect of Cedrol, a sesquiterpene… read more here.
Keywords: dna damage; cell; gbm; cedrol ... See more keywords
Nuclear translocation of STAT3 and NF-κB are independent of each other but NF-κB supports expression and activation of STAT3.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2017.01.006
Abstract: NF-κB and STAT3 are essential transcription factors in immunity and act at the interface of the transition from chronic inflammation to cancer. Different functional crosstalks between NF-κB and STAT3 have been recently described arguing for… read more here.
Keywords: transcription; stat3; expression; activation ... See more keywords
CgIL17-5 regulates the mRNA expressions of immune effectors through inducing the phosphorylation of CgMAPKs and the nuclear translocation of CgRel and CgAP-1 in the Pacific oyster Crassostrea gigas.
Sign Up to like & getrecommendations! Published in 2021 at "Developmental and comparative immunology"
DOI: 10.1016/j.dci.2021.104263
Abstract: Interleukin-17 (IL-17) is a classic pro-inflammatory cytokine that plays an important role in the immune and inflammatory response. In the present study, the sequence feature of CgIL17-5 and its function as a pro-inflammatory factor in… read more here.
Keywords: cgil17; mrna expressions; cgrel cgap; nuclear translocation ... See more keywords
RAPGEF5 Regulates Nuclear Translocation of β-Catenin.
Sign Up to like & getrecommendations! Published in 2018 at "Developmental cell"
DOI: 10.1016/j.devcel.2017.12.001
Abstract: Canonical Wnt signaling coordinates many critical aspects of embryonic development, while dysregulated Wnt signaling contributes to common diseases, including congenital malformations and cancer. The nuclear localization of β-catenin is the defining step in pathway activation.… read more here.
Keywords: wnt signaling; rapgef5; catenin; regulates nuclear ... See more keywords
IL-6 promotes nuclear translocation of HIF-1α to aggravate chemoresistance of ovarian cancer cells.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173817
Abstract: The inflammatory milieu in tumor modulates the resistance to the conventional antitumoral therapies. Interleukin-6 (IL-6), a pleiotropic pro-inflammatory cytokine and a crucial mediator of tumor development, has been targeted as a therapeutic strategy to overcome… read more here.
Keywords: hif; chemoresistance; translocation hif; promotes nuclear ... See more keywords
Piceatannol effectively counteracts glyceraldehyde-3-phosphate dehydrogenase aggregation and nuclear translocation in hippocampal cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2019.05.002
Abstract: Abstract There is increasing evidence that supplementation with superfoods is one of the available solution to prevent or slow down the progression of neurodegenerative diseases. Especially polyphenols have been reported to exert strong neuroprotective properties.… read more here.
Keywords: glyceraldehyde phosphate; aggregation; nuclear translocation; phosphate dehydrogenase ... See more keywords
Icariin inhibits LPS‐induced cell inflammatory response by promoting GR&agr; nuclear translocation and upregulating GR&agr; expression
Sign Up to like & getrecommendations! Published in 2018 at "Life Sciences"
DOI: 10.1016/j.lfs.2018.01.006
Abstract: Aims: Icariin (ICA) is a flavonoid isolated from certain plant species in the genus Epimedium, especially Epimedium brevicornum. Previous studies indicated that ICA has certain regulatory effects on some inflammatory diseases, and that ICA regulates… read more here.
Keywords: ica; agr nuclear; expression; cell ... See more keywords