Nuclear transport proteins are secreted by cancer cells and identified as potential novel cancer biomarkers.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of cancer"
DOI: 10.1002/ijc.33832
Abstract: Previous studies have identified increased expression of members of the nuclear transport protein family in cancer cells. Recently, certain nuclear transport proteins have been reported to be secreted by cells and found in the serum.… read more here.
Keywords: nuclear transport; transport proteins; proteins secreted; cancer cells ... See more keywords
Karyopherins in cancer.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in cell biology"
DOI: 10.1016/j.ceb.2018.01.006
Abstract: Malfunction of nuclear-cytoplasmic transport contributes to many diseases including cancer. Defective nuclear transport leads to changes in both the physiological levels and temporal-spatial location of tumor suppressors, proto-oncogenes and other macromolecules that in turn affect… read more here.
Keywords: nuclear transport; transport; karyopherins cancer; biology ... See more keywords
Heat stress-induced nuclear transport mediated by Hikeshi confers nuclear function of Hsp70s.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in cell biology"
DOI: 10.1016/j.ceb.2018.02.010
Abstract: The prime feature of eukaryotic cells is the separation of the intracellular space into two compartments, the nucleus and the cytoplasm. Active nuclear transport is crucial for the maintenance of this separation. In this report,… read more here.
Keywords: function; nuclear transport; heat stress;
Role of karyopherin nuclear transport receptors in nuclear transport by nuclear trafficking peptide.
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DOI: 10.1016/j.yexcr.2021.112893
Abstract: Nuclear trafficking peptide (NTP), a cell-penetrating peptide (CPP) composed of 10 amino acids (aa) (RIFIHFRIGC), has potent nuclear trafficking activity. Recently, we established a protein-based cell engineering system by using NTP, but it remained elusive… read more here.
Keywords: nuclear transport; vpr; transport; nuclear trafficking ... See more keywords
Structural and mechanistic insights into nuclear transport and delivery of the critical pluripotency factor Oct4 to DNA
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2017.1289124
Abstract: Oct4 is a master regulator of the induction and maintenance of cellular pluripotency, and has crucial roles in early stages of differentiation. It is the only factor that cannot be substituted by other members of… read more here.
Keywords: nuclear transport; importin; dna; delivery ... See more keywords
Nuclear transport genes recurrently duplicate by means of RNA intermediates in Drosophila but not in other insects
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DOI: 10.1186/s12864-021-08170-4
Abstract: Background The nuclear transport machinery is involved in a well-known male meiotic drive system in Drosophila . Fast gene evolution and gene duplications have been major underlying mechanisms in the evolution of meiotic drive systems,… read more here.
Keywords: insects; nuclear transport; meiotic drive; gene ... See more keywords
ROCK‐dependent phosphorylation of NUP62 regulates p63 nuclear transport and squamous cell carcinoma proliferation
Sign Up to like & getrecommendations! Published in 2018 at "EMBO reports"
DOI: 10.15252/embr.201744523
Abstract: p63, more specifically its ΔNp63α isoform, plays essential roles in squamous cell carcinomas (SCCs), yet the mechanisms controlling its nuclear transport remain unknown. Nucleoporins (NUPs) are a family of proteins building nuclear pore complexes (NPC)… read more here.
Keywords: nuclear transport; squamous cell; transport; nup62 ... See more keywords
Landscape of nuclear transport receptor cargo specificity
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DOI: 10.15252/msb.20177608
Abstract: Nuclear transport receptors (NTRs) recognize localization signals of cargos to facilitate their passage across the central channel of nuclear pore complexes (NPCs). About 30 different NTRs constitute different transport pathways in humans and bind to… read more here.
Keywords: nuclear transport; landscape nuclear; transport; transport receptor ... See more keywords
Measuring and Interpreting Nuclear Transport in Neurodegenerative Disease—The Example of C9orf72 ALS
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DOI: 10.3390/ijms22179217
Abstract: Transport from and into the nucleus is essential to all eukaryotic life and occurs through the nuclear pore complex (NPC). There are a multitude of data supporting a role for nuclear transport in neurodegenerative diseases,… read more here.
Keywords: nuclear transport; transport; example; disease ... See more keywords