Molecular basis of stepwise cyclic tetra-adenylate cleavage by the type III CRISPR ring nuclease Crn1/Sso2081
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DOI: 10.1101/2022.10.01.510428
Abstract: The cyclic oligoadenylates (cOAs) act as second messengers of type III CRISPR immunity system through activating the auxiliary nucleases for indiscriminate RNA degradation. The cOA-degrading nucleases (ring nucleases) provide an ‘off-switch’ regulation of the signaling,… read more here.
Keywords: ring nuclease; cleavage; type iii; nuclease crn1 ... See more keywords