Evaluating and Enhancing Target Specificity of Gene-Editing Nucleases and Deaminases.
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DOI: 10.1146/annurev-biochem-013118-111730
Abstract: Programmable nucleases and deaminases, which include zinc-finger nucleases, transcription activator-like effector nucleases, CRISPR RNA-guided nucleases, and RNA-guided base editors, are now widely employed for the targeted modification of genomes in cells and organisms. These gene-editing… read more here.
Keywords: target activity; gene editing; nucleases deaminases; target ... See more keywords