Fusobacterium nucleatum impairs DNA mismatch repair and stability in patients with squamous cell carcinoma of the head and neck
Sign Up to like & getrecommendations! Published in 2022 at "Cancer"
DOI: 10.1002/cncr.34338
Abstract: Dysbiosis of the laryngeal microbiota has been demonstrated to the development of head and neck squamous cell carcinoma (HNSCC), but the association of Fusobacterium and Fusobacterium nucleatum (F. nucleatum) with DNA mismatch repair (MMR) and… read more here.
Keywords: fusobacterium nucleatum; cell carcinoma; head neck; squamous cell ... See more keywords
Fusobacterium nucleatum mediates endothelial damage and increased permeability following single species and polymicrobial infection
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Periodontology"
DOI: 10.1002/jper.21-0671
Abstract: Abstract Background Numerous lines of evidence link periodontal pathobionts and their virulence factors with endothelial damage. Most research has been conducted using single species infections at the exclusion of other periodontal microorganisms that have been… read more here.
Keywords: infection; polymicrobial infection; endothelial damage; permeability ... See more keywords
Coaggregated E. faecalis with F. nucleatum regulated environmental stress responses and inflammatory effects
Sign Up to like & getrecommendations! Published in 2024 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-024-13172-9
Abstract: Abstract To investigate the cell-cell interactions of intergeneric bacterial species, the study detected the survival of Enterococcus faecalis (Ef) under monospecies or coaggregation state with Fusobacterium nucleatum subsp. polymorphum (Fnp) in environmental stress. Ef and… read more here.
Keywords: fnp; coaggregation fnp; environmental stress; coaggregation ... See more keywords
Expression, Purification, and Characterization of the Recombinant, Two-Component, Response Regulator ArlR from Fusobacterium nucleatum
Sign Up to like & getrecommendations! Published in 2022 at "Applied Biochemistry and Biotechnology"
DOI: 10.1007/s12010-021-03785-5
Abstract: Fusobacterium nucleatum is associated with the incidence and development of multiple diseases, such as periodontitis and colorectal cancer (CRC). Until now, studies have proved only a few proteins to be associated with such pathogenic diseases.… read more here.
Keywords: response regulator; expression; nucleatum; expression purification ... See more keywords
Engineering Short Antimicrobial Peptides to Specifically Target Fusobacterium nucleatum in the Mixed Microbial Population.
Sign Up to like & getrecommendations! Published in 2024 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.4c00387
Abstract: Antimicrobial peptides (AMPs) are becoming next-generation alternative antibacterial agents because of the rapid increase in resistance in bacteria against existing antibiotics, which can also be attributed to the formation of resilient biofilms. However, their widespread… read more here.
Keywords: engineering short; nucleatum; fusobacterium nucleatum; short antimicrobial ... See more keywords
Modulation of Intratumoral Fusobacterium nucleatum to Enhance Sonodynamic Therapy for Colorectal Cancer with Reduced Phototoxic Skin Injury.
Sign Up to like & getrecommendations! Published in 2023 at "ACS nano"
DOI: 10.1021/acsnano.3c01308
Abstract: Intratumoral pathogens can contribute to cancer progression and affect therapeutic response. Fusobacterium nucleatum, a core pathogen of colorectal cancer (CRC), is an important cause of low therapeutic efficacy and metastasis. Thus, the modulation of intratumoral… read more here.
Keywords: nucleatum; therapy; colorectal cancer; enhance ... See more keywords
Intratumoral presence of the genotoxic gut bacteria pks+ E. coli, Enterotoxigenic Bacteroides fragilis, and Fusobacterium nucleatum and their association with clinicopathological and molecular features of colorectal cancer
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DOI: 10.1038/s41416-023-02554-x
Abstract: This study aimed to investigate clinicopathological and molecular tumour features associated with intratumoral pks+Escherichia coli (pks+E.coli+), pks+E.coli- (non-E.coli bacteria harbouring the pks island), Enterotoxigenic Bacteroides fragilis (ETBF) and Fusobacterium nucleatum (F. nucleatum). We screened 1697… read more here.
Keywords: pks coli; cancer; enterotoxigenic bacteroides; pks ... See more keywords
Fusobacterium nucleatum promotes tumor progression in KRAS p.G12D-mutant colorectal cancer by binding to DHX15
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DOI: 10.1038/s41467-024-45572-w
Abstract: Fusobacterium nucleatum (F. nucleatum) promotes intestinal tumor growth and its relative abundance varies greatly among patients with CRC, suggesting the presence of unknown, individual-specific effectors in F. nucleatum-dependent carcinogenesis. Here, we identify that F. nucleatum… read more here.
Keywords: crc; g12d mutant; nucleatum promotes; fusobacterium nucleatum ... See more keywords
Decrease from main root canal and intratubular Fusobacterium nucleatum and its endotoxin after ultrasonic activation of conventional and alternative irrigation solutions
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DOI: 10.1080/08927014.2024.2426765
Abstract: Abstract This study evaluated conventional and alternative irrigation solutions combined with ultrasonic irrigant activation (UIA) against Fusobacterium nucleatum (F. nucleatum) and its endotoxin (LPS) in main root canal and dentinal tubules, using a new intratubular… read more here.
Keywords: conventional alternative; alternative irrigation; activation; irrigation ... See more keywords
Effect of a bacteriocin-producing Streptococcus salivarius on the pathogen Fusobacterium nucleatum in a model of the human distal colon
Sign Up to like & getrecommendations! Published in 2022 at "Gut Microbes"
DOI: 10.1080/19490976.2022.2100203
Abstract: ABSTRACT The gut microbiome is a vast reservoir of microbes, some of which produce antimicrobial peptides called bacteriocins that may inhibit specific bacteria associated with disease. Fusobacterium nucleatum is an emerging human bacterial pathogen associated… read more here.
Keywords: crc; salivarius dpc6993; fusobacterium; nucleatum ... See more keywords
Fusobacterium nucleatum and its associated systemic diseases: epidemiologic studies and possible mechanisms
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DOI: 10.1080/20002297.2022.2145729
Abstract: ABSTRACT Background Fusobacterium nucleatum (F. nucleatum) is an anaerobic oral commensal and the major coaggregation bridge organism linking early and late colonisers. In recent years, a large number of studies suggest that F. nucleatum is… read more here.
Keywords: systemic diseases; nucleatum associated; nucleatum; associated systemic ... See more keywords