Sensitivity and Diagnostic Yield of the First SARS-CoV-2 Nucleic Acid Amplification Test Performed for Patients Presenting to the Hospital
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.36288
Abstract: Key Points Question What is the diagnostic sensitivity of the SARS-CoV-2 nucleic acid amplification test (NAAT) by date of symptom onset among patients presenting to the hospital? Findings In this diagnostic study, the sensitivity of… read more here.
Keywords: cov nucleic; sensitivity; test; patients presenting ... See more keywords
Charge‐Conversion Strategies for Nucleic Acid Delivery
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DOI: 10.1002/adfm.202011103
Abstract: Nucleic acids are considered as one of the most potent therapeutic modalities, as their roles go beyond storing genetic information and chemical energy or as signal transducers. Attenuation or expression of desired genes through nucleic… read more here.
Keywords: nucleic acids; delivery; charge conversion; charge ... See more keywords
Lipid Nanoparticles for Broad‐Spectrum Nucleic Acid Delivery
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DOI: 10.1002/adfm.202101391
Abstract: Lipid nanoparticles (LNPs) are the most advanced nonviral modality for nucleic acid (NA) delivery, and have recently gained enormous attention in the fields of RNA therapeutics and vaccine development. Here, ionizable adamantane‐based lipidoids named XMaNs,… read more here.
Keywords: lipid nanoparticles; delivery; acid delivery; nanoparticles broad ... See more keywords
Gene Therapy Based on Nucleic Acid Nanostructure.
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DOI: 10.1002/adhm.202001046
Abstract: During the past decades, nucleic acids have been employed for the construction of versatile nanostructures with well-defined shapes and sizes. Owing to the remarkable programmability, addressability, and biocompatibility, nucleic acid nanostructures are extensively applied in… read more here.
Keywords: therapy based; gene; nucleic acid; gene therapy ... See more keywords
Recent Advances in Microfluidics for Nucleic Acid Analysis of Small Extracellular Vesicles in Cancer
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DOI: 10.1002/adhm.202401295
Abstract: Small extracellular vesicles (sEVs) are membranous vesicles released from cellular structures through plasma membrane budding. These vesicles contain cellular components such as proteins, lipids, mRNAs, microRNAs, long‐noncoding RNA, circular RNA, and double‐stranded DNA, originating from… read more here.
Keywords: extracellular vesicles; nucleic acid; cancer; advances microfluidics ... See more keywords
A Virus-Mimicking Nucleic Acid Nanogel Reprograms Microglia and Macrophages for Glioblastoma Therapy.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced materials"
DOI: 10.1002/adma.202006116
Abstract: Immunotherapy is recognized as one of the most promising approaches to treat cancers. However, its effect in glioblastoma (GBM) treatment is insufficient, which can in part be attributed to the immunosuppressive tumor microenvironment (TME). Microglia… read more here.
Keywords: nucleic acid; virus mimicking; microglia macrophages; acid nanogel ... See more keywords
Molecular Chameleon Carriers for Nucleic Acid Delivery: The Sweet Spot Between Lipoplexes and Polyplexes.
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DOI: 10.1002/adma.202211105
Abstract: Taking advantage of effective intracellular delivery mechanisms of both cationizable lipids and polymers, highly potent double pH-responsive nucleic acid carriers were generated by combining at least two lipo amino fatty acids (LAFs) as hydrophobic cationizable… read more here.
Keywords: chameleon carriers; molecular chameleon; nucleic acid; acid delivery ... See more keywords
Smart and Functionalized Development of Nucleic Acid‐Based Hydrogels: Assembly Strategies, Recent Advances, and Challenges
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DOI: 10.1002/advs.202100216
Abstract: Abstract Nucleic acid‐based hydrogels that integrate intrinsic biological properties of nucleic acids and mechanical behavior of their advanced assemblies are appealing bioanalysis and biomedical studies for the development of new‐generation smart biomaterials. It is inseparable… read more here.
Keywords: based hydrogels; acid based; assembly strategies; nucleic acid ... See more keywords
Deep‐dLAMP: Deep Learning‐Enabled Polydisperse Emulsion‐Based Digital Loop‐Mediated Isothermal Amplification
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DOI: 10.1002/advs.202105450
Abstract: Abstract Digital nucleic acid amplification tests enable absolute quantification of nucleic acids, but the generation of uniform compartments and reading of the fluorescence requires specialized instruments that are costly, limiting their widespread applications. Here, the… read more here.
Keywords: dlamp; amplification; deep dlamp; deep learning ... See more keywords
Cryo‐X‐Ray Phase Contrast Imaging Enables Combined 3D Structural Quantification and Nucleic Acid Analysis of Myocardial Biopsies
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DOI: 10.1002/advs.202409163
Abstract: Snap‐frozen biopsies serve as a valuable clinical resource of archival material for disease research, as they enable a comprehensive array of downstream analyses to be performed, including extraction and sequencing of nucleic acids. Obtaining three‐dimensional… read more here.
Keywords: nucleic acid; phase contrast; ray phase; analysis ... See more keywords
Deep Learning‐Enhanced Hand‐Driven Microfluidic Chip for Multiplexed Nucleic Acid Detection Based on RPA/CRISPR
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202414918
Abstract: The early detection of high‐risk human papillomavirus (HR‐HPV) is crucial for the assessment and improvement of prognosis in cervical cancer. However, existing PCR‐based screening methods suffer from inadequate accessibility, which dampens the enthusiasm for screening… read more here.
Keywords: detection; hpv; nucleic acid; multiplexed nucleic ... See more keywords