Inhibition of nonenzymatic depurination of nucleic acids by polycations
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12308
Abstract: DNA base depurination is one of the most common forms of DNA damage in vivo and in vitro, and the suppression of depurination is very important for versatile applications of DNA in biotechnology and medicine.… read more here.
Keywords: acids polycations; nucleic acids; inhibition nonenzymatic; nonenzymatic depurination ... See more keywords
Charge‐Conversion Strategies for Nucleic Acid Delivery
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DOI: 10.1002/adfm.202011103
Abstract: Nucleic acids are considered as one of the most potent therapeutic modalities, as their roles go beyond storing genetic information and chemical energy or as signal transducers. Attenuation or expression of desired genes through nucleic… read more here.
Keywords: nucleic acids; delivery; charge conversion; charge ... See more keywords
Harnessing the Therapeutic Potential of Biomacromolecules through Intracellular Delivery of Nucleic Acids, Peptides, and Proteins
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202102600
Abstract: Biomacromolecules have long been at the leading edge of academic and pharmaceutical drug development and clinical translation. With the clinical advances of new therapeutics, such as monoclonal antibodies and nucleic acids, the array of medical… read more here.
Keywords: nucleic acids; therapeutic potential; harnessing therapeutic; intracellular delivery ... See more keywords
Modulation of the Crosstalk between Schwann Cells and Macrophages for Nerve Regeneration: A Therapeutic Strategy Based on a Multifunctional Tetrahedral Framework Nucleic Acids System
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202202513
Abstract: Peripheral nerve injury (PNI) is currently recognized as one of the most significant public health issues and affects the general well‐being of millions of individuals worldwide. Despite advances in nerve tissue engineering, nerve repair still… read more here.
Keywords: regeneration; multifunctional tetrahedral; tetrahedral framework; framework nucleic ... See more keywords
Nucleic Acids as a Nature‐Inspired Scaffold for Macromolecular Prodrugs of Nucleoside Analogues
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DOI: 10.1002/advs.201802095
Abstract: Abstract Macromolecular prodrugs (MP) built on the natural phosphodiester and deoxyribose backbone are developed using marketed antiviral nucleoside analogues. These MP are synthesized using automated synthesis, have defined molecular composition, and have a natural mechanism… read more here.
Keywords: acids nature; nucleic acids; nature inspired; nucleoside analogues ... See more keywords
The Transpeptidase Sortase A Binds Nucleic Acids and Mediates Mammalian Cell Labeling
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DOI: 10.1002/advs.202305605
Abstract: Wild‐type sortase A is an important virulence factor displaying a diverse array of proteins on the surface of bacteria. This protein display relies on the transpeptidase activity of sortase A, which is widely engineered to… read more here.
Keywords: sortase binds; wild type; sortase; cell labeling ... See more keywords
Engineering Liquid Hierarchical Materials with DNA‐Programmed Spherical Nucleic Acids
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DOI: 10.1002/advs.202504471
Abstract: Inspired by nature, the orchestration of self‐assembling building blocks into hierarchical superstructures offers a transformative approach to functional materials design. While significant advances have been made in engineering solid‐state hierarchical materials such as crystals and… read more here.
Keywords: spherical nucleic; hierarchical materials; engineering; liquid hierarchical ... See more keywords
Marginal Stability of the YB1 Cold-Shock Domain in Cells Enables Binding of Multiple Nucleic Acids.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced science"
DOI: 10.1002/advs.202512966
Abstract: YB1 is an intrinsically disordered protein with a folded cold shock domain (CSD) required for translation, transcription, and RNA metabolism. This multifunctionality and cancer involvement make it a therapeutically attractive target. YB1‐CSD and nucleic acid… read more here.
Keywords: cold shock; stability; yb1; shock domain ... See more keywords
Nucleic acids movement and its relation to genome dynamics of repetitive DNA
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DOI: 10.1002/bies.202100242
Abstract: There is growing evidence of evolutionary genome plasticity. The evolution of repetitive DNA elements, the major components of most eukaryotic genomes, involves the amplification of various classes of mobile genetic elements, the expansion of satellite… read more here.
Keywords: dna; repetitive dna; acids movement; genome ... See more keywords
Cyclopentane peptide nucleic acid: Gold nanoparticle conjugates for the detection of nucleic acids in a microfluidic format.
Sign Up to like & getrecommendations! Published in 2021 at "Biopolymers"
DOI: 10.1002/bip.23481
Abstract: Routine patient testing for viral infections is critical to identify infected individuals for treatment and to prevent spreading of infections to others. Developing robust and reliable diagnostic tools to detect nucleic acids of viruses at… read more here.
Keywords: detection; cyclopentane; nucleic acids; peptide nucleic ... See more keywords
New Fluorescent Nanoparticles for Ultrasensitive Detection of Nucleic Acids by Optical Methods
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DOI: 10.1002/cbic.201700125
Abstract: For decades the detection of nucleic acids and their interactions at low abundances has been a challenging task that has thus far been solved by enzymatic target amplification. In this work we aimed at developing… read more here.
Keywords: detection; fluorescent nanoparticles; nucleic acids; ultrasensitive detection ... See more keywords