Inhibition of nonenzymatic depurination of nucleic acids by polycations
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DOI: 10.1002/2211-5463.12308
Abstract: DNA base depurination is one of the most common forms of DNA damage in vivo and in vitro, and the suppression of depurination is very important for versatile applications of DNA in biotechnology and medicine.… read more here.
Keywords: acids polycations; nucleic acids; inhibition nonenzymatic; nonenzymatic depurination ... See more keywords
Charge‐Conversion Strategies for Nucleic Acid Delivery
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DOI: 10.1002/adfm.202011103
Abstract: Nucleic acids are considered as one of the most potent therapeutic modalities, as their roles go beyond storing genetic information and chemical energy or as signal transducers. Attenuation or expression of desired genes through nucleic… read more here.
Keywords: nucleic acids; delivery; charge conversion; charge ... See more keywords
Harnessing the Therapeutic Potential of Biomacromolecules through Intracellular Delivery of Nucleic Acids, Peptides, and Proteins
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DOI: 10.1002/adhm.202102600
Abstract: Biomacromolecules have long been at the leading edge of academic and pharmaceutical drug development and clinical translation. With the clinical advances of new therapeutics, such as monoclonal antibodies and nucleic acids, the array of medical… read more here.
Keywords: nucleic acids; therapeutic potential; harnessing therapeutic; intracellular delivery ... See more keywords
Modulation of the Crosstalk between Schwann Cells and Macrophages for Nerve Regeneration: A Therapeutic Strategy Based on a Multifunctional Tetrahedral Framework Nucleic Acids System
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DOI: 10.1002/adma.202202513
Abstract: Peripheral nerve injury (PNI) is currently recognized as one of the most significant public health issues and affects the general well‐being of millions of individuals worldwide. Despite advances in nerve tissue engineering, nerve repair still… read more here.
Keywords: regeneration; multifunctional tetrahedral; tetrahedral framework; framework nucleic ... See more keywords
Nucleic Acids as a Nature‐Inspired Scaffold for Macromolecular Prodrugs of Nucleoside Analogues
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DOI: 10.1002/advs.201802095
Abstract: Abstract Macromolecular prodrugs (MP) built on the natural phosphodiester and deoxyribose backbone are developed using marketed antiviral nucleoside analogues. These MP are synthesized using automated synthesis, have defined molecular composition, and have a natural mechanism… read more here.
Keywords: acids nature; nucleic acids; nature inspired; nucleoside analogues ... See more keywords
Nucleic acids movement and its relation to genome dynamics of repetitive DNA
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DOI: 10.1002/bies.202100242
Abstract: There is growing evidence of evolutionary genome plasticity. The evolution of repetitive DNA elements, the major components of most eukaryotic genomes, involves the amplification of various classes of mobile genetic elements, the expansion of satellite… read more here.
Keywords: dna; repetitive dna; acids movement; genome ... See more keywords
Cyclopentane peptide nucleic acid: Gold nanoparticle conjugates for the detection of nucleic acids in a microfluidic format.
Sign Up to like & getrecommendations! Published in 2021 at "Biopolymers"
DOI: 10.1002/bip.23481
Abstract: Routine patient testing for viral infections is critical to identify infected individuals for treatment and to prevent spreading of infections to others. Developing robust and reliable diagnostic tools to detect nucleic acids of viruses at… read more here.
Keywords: detection; cyclopentane; nucleic acids; peptide nucleic ... See more keywords
New Fluorescent Nanoparticles for Ultrasensitive Detection of Nucleic Acids by Optical Methods
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DOI: 10.1002/cbic.201700125
Abstract: For decades the detection of nucleic acids and their interactions at low abundances has been a challenging task that has thus far been solved by enzymatic target amplification. In this work we aimed at developing… read more here.
Keywords: detection; fluorescent nanoparticles; nucleic acids; ultrasensitive detection ... See more keywords
γ‐(S)‐Guanidinylmethyl‐Modified Triplex‐Forming Peptide Nucleic Acids Increase Hoogsteen‐Face Affinity for a MicroRNA and Enhance Cellular Uptake
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DOI: 10.1002/cbic.201900393
Abstract: γ‐Modified (i.e., (S)‐aminomethyl, (S)‐acetamidomethyl, (R)‐4‐(hydroxymethyl)triazol‐1‐ylmethyl, and (S)‐guanidinylmethyl) triplex‐forming peptide nucleic acids (TFPNAs) were synthesized and the effect of the backbone modifications on the binding to a miR‐215 model was studied. Among the modifications, an appropriate… read more here.
Keywords: nucleic acids; peptide nucleic; guanidinylmethyl; forming peptide ... See more keywords
Stable Hairpin Structures Formed by Xylose‐Based Nucleic Acids
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DOI: 10.1002/cbic.202000803
Abstract: Xenobiology explores synthetic nucleic acid polymers as alternative carriers of genetic information to expand the central dogma. The xylo‐ and deoxyxylo‐nucleic acids (XyNA and dXyNA), containing 3’ epimers of riboses and deoxyriboses, are considered to… read more here.
Keywords: structures formed; stable hairpin; nucleic acids; xylose based ... See more keywords
Stacked Thiazole Orange Dyes in DNA Capable of Switching Emissive Behavior in Response to Structural Transitions
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DOI: 10.1002/cbic.202100309
Abstract: Functional nucleic acids with the capability of generating fluorescence in response to hybridization events, microenvironment or structural changes are valuable as structural probes and chemical sensors. We now demonstrate the enzyme‐assisted preparation of nucleic acids… read more here.
Keywords: response; dna; nucleic acids; thiazole orange ... See more keywords