Nucleocytoplasmic transport defect in a North American patient with ALS8
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.515
Abstract: Amyotrophic lateral sclerosis 8 (ALS8) is a rare progressive neurodegenerative disease resulting from mutation in the gene for vesicle‐associated membrane protein‐associated protein B. We evaluated a North American patient using exome sequencing, and identified a… read more here.
Keywords: american patient; north american; als8; nucleocytoplasmic transport ... See more keywords
Saturated fatty acids entrap PDX1 in stress granules and impede islet beta cell function
Sign Up to like & getrecommendations! Published in 2021 at "Diabetologia"
DOI: 10.1007/s00125-021-05389-4
Abstract: Failure of pancreatic and duodenal homeobox factor 1 (PDX1) to localise in the nucleus of islet beta cells under high-fat diet (HFD) conditions may be an early functional defect that contributes to beta cell failure… read more here.
Keywords: formation; beta; nucleocytoplasmic transport; beta cell ... See more keywords
Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2019 at "Neuron"
DOI: 10.1016/j.neuron.2018.12.031
Abstract: Bahareh Eftekharzadeh, J. Gavin Daigle, Larisa E. Kapinos, Alyssa Coyne, Julia Schiantarelli, Yari Carlomagno, Casey Cook, Sean J. Miller, Simon Dujardin, Ana S. Amaral, Jonathan C. Grima, Rachel E. Bennett, Katharina Tepper, Michael DeTure, Charles… read more here.
Keywords: alzheimer disease; protein disrupts; disrupts nucleocytoplasmic; nucleocytoplasmic transport ... See more keywords
The role of nucleocytoplasmic transport in mechanotransduction.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2019.02.009
Abstract: Cells integrate mechanical and biochemical signals via a process called mechanotransduction to generate essential gene expression patterns in space and time. This is vital for cell migration and proliferation as well as tissue morphogenesis and… read more here.
Keywords: transport mechanotransduction; role nucleocytoplasmic; transport; force ... See more keywords
Fluorescence-based quantification of nucleocytoplasmic transport.
Sign Up to like & getrecommendations! Published in 2019 at "Methods"
DOI: 10.1016/j.ymeth.2018.11.002
Abstract: The sequestration of DNA within the membrane-bound nucleus is a defining characteristic of eukaryotic cells. Replication and transcription are therefore restricted to the nucleus, however, the regulation of these events relies on cytoplasmic processes including… read more here.
Keywords: based quantification; fluorescence based; transport; nucleocytoplasmic transport ... See more keywords
TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD
Sign Up to like & getrecommendations! Published in 2017 at "Nature neuroscience"
DOI: 10.1038/s41593-017-0047-3
Abstract: The cytoplasmic mislocalization and aggregation of TAR DNA-binding protein-43 (TDP-43) is a common histopathological hallmark of the amyotrophic lateral sclerosis and frontotemporal dementia disease spectrum (ALS/FTD). However, the composition of aggregates and their contribution to… read more here.
Keywords: tdp; pathology; als ftd; nucleocytoplasmic transport ... See more keywords
Tau-FG-nucleoporin98 interaction and impaired nucleocytoplasmic transport in Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in functional genomics"
DOI: 10.1093/bfgp/elac022
Abstract: An emerging pathophysiology associated with the neurodegenerative Alzheimer's disease (AD) is the impairment of nucleocytoplasmic transport (NCT). The impairment can originate from damage to the nuclear pore complex (NPC) or other factors involved in NCT.… read more here.
Keywords: interaction; alzheimer disease; nucleocytoplasmic transport;
SARS-CoV-2 ORF6 Disrupts Bidirectional Nucleocytoplasmic Transport through Interactions with Rae1 and Nup98
Sign Up to like & getrecommendations! Published in 2021 at "mBio"
DOI: 10.1128/mbio.00065-21
Abstract: SARS-CoV-2, the causative agent of coronavirus disease 2019 (COVID-19), is an RNA virus with a large genome that encodes multiple accessory proteins. While these accessory proteins are not required for growth in vitro, they can… read more here.
Keywords: rae1 nup98; mrna; interactions rae1; cov orf6 ... See more keywords
CBP-Mediated Acetylation of Importin α Mediates Calcium-Dependent Nucleocytoplasmic Transport of Selective Proteins in Drosophila Neurons
Sign Up to like & getrecommendations! Published in 2022 at "Molecules and Cells"
DOI: 10.14348/molcells.2022.0104
Abstract: For proper function of proteins, their subcellular localization needs to be monitored and regulated in response to the changes in cellular demands. In this regard, dysregulation in the nucleocytoplasmic transport (NCT) of proteins is closely… read more here.
Keywords: atxn3; nucleocytoplasmic transport; nct atxn3; atxn3 proteins ... See more keywords
Traumatic injury compromises nucleocytoplasmic transport and leads to TDP-43 pathology
Sign Up to like & getrecommendations! Published in 2021 at "eLife"
DOI: 10.7554/elife.67587
Abstract: Traumatic brain injury (TBI) is a predisposing factor for many neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD), Parkinson’s disease (PD), and chronic traumatic encephalopathy (CTE). Although defects in nucleocytoplasmic transport (NCT) is… read more here.
Keywords: pathology; nucleocytoplasmic transport; traumatic injury; tdp pathology ... See more keywords