Nucleolar Localization of HIV-1 Rev Is Required, Yet Insufficient for Production of Infectious Viral Particles
Sign Up to like & getrecommendations! Published in 2018 at "AIDS Research and Human Retroviruses"
DOI: 10.1089/aid.2017.0306
Abstract: Abstract Combination antiretroviral therapy fails in complete suppression of HIV-1 due to drug resistance and persistent latency. Novel therapeutic intervention requires knowledge of intracellular pathways responsible for viral replication, specifically those untargeted by antiretroviral drugs.… read more here.
Keywords: production; rev; hiv; nucleolar localization ... See more keywords
A Novel TAF1C Missense Variant Causes Neurodevelopmental Regression via Disrupted Nucleolar Localization and Nucleoplasmic Aggregation
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DOI: 10.1111/cge.14771
Abstract: TAF1C (TATA box‐binding protein‐associated factor, RNA polymerase I subunit C) is an essential component of the RNA polymerase I transcription machinery responsible for ribosomal RNA synthesis and nucleolar function. Variants in TAF1C have recently emerged… read more here.
Keywords: taf1c; nucleolar localization; missense variant; variant causes ... See more keywords
Internal Associations of the Acidic Region of Upstream Binding Factor Control Its Nucleolar Localization
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DOI: 10.1128/mcb.00218-17
Abstract: ABSTRACT Upstream binding factor (UBF) is a member of the high-mobility group (HMG) box protein family, characterized by multiple HMG boxes and a C-terminal acidic region (AR). UBF is an essential transcription factor for rRNA… read more here.
Keywords: upstream binding; hmg; nucleolar localization; factor ... See more keywords
Sirtuin1 meditated modification of Notch1 intracellular domain regulates nucleolar localization and activation of distinct signaling cascades
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.988816
Abstract: Notch signaling is involved in cell fate decisions in the development and maintenance of tissue homeostasis. Spatial regulation of the Notch1 intracellular domain (NIC1), has been shown to underpin signaling outcomes mediated by this receptor.… read more here.
Keywords: localization; anti apoptotic; notch1 intracellular; nucleolar localization ... See more keywords