Nucleolar Localization of HIV-1 Rev Is Required, Yet Insufficient for Production of Infectious Viral Particles
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DOI: 10.1089/aid.2017.0306
Abstract: Abstract Combination antiretroviral therapy fails in complete suppression of HIV-1 due to drug resistance and persistent latency. Novel therapeutic intervention requires knowledge of intracellular pathways responsible for viral replication, specifically those untargeted by antiretroviral drugs.… read more here.
Keywords: production; rev; hiv; nucleolar localization ... See more keywords
Internal Associations of the Acidic Region of Upstream Binding Factor Control Its Nucleolar Localization
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DOI: 10.1128/mcb.00218-17
Abstract: ABSTRACT Upstream binding factor (UBF) is a member of the high-mobility group (HMG) box protein family, characterized by multiple HMG boxes and a C-terminal acidic region (AR). UBF is an essential transcription factor for rRNA… read more here.
Keywords: upstream binding; hmg; nucleolar localization; factor ... See more keywords
Sirtuin1 meditated modification of Notch1 intracellular domain regulates nucleolar localization and activation of distinct signaling cascades
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DOI: 10.3389/fcell.2022.988816
Abstract: Notch signaling is involved in cell fate decisions in the development and maintenance of tissue homeostasis. Spatial regulation of the Notch1 intracellular domain (NIC1), has been shown to underpin signaling outcomes mediated by this receptor.… read more here.
Keywords: localization; anti apoptotic; notch1 intracellular; nucleolar localization ... See more keywords