TARGETING P53 AND NUCLEOLAR STRESS IN DIAMOND-BLACKFAN ANAEMIA
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Hematology"
DOI: 10.1016/j.exphem.2019.06.372
Abstract: Diamond-Blackfan anaemia (DBA) is a rare congenital erythroid hypoplastic anaemia characterised by severely reduced numbers of erythroid precursors in the bone marrow. This reduction of erythroid progenitors is partly due to p53-induced apoptosis during erythroid… read more here.
Keywords: p53; diamond blackfan; nucleolar stress; blackfan anaemia ... See more keywords
Nanoscopic Imaging of Nucleolar Stress Enabled by Protein-Mimicking Carbon Dots.
Sign Up to like & getrecommendations! Published in 2021 at "Nano letters"
DOI: 10.1021/acs.nanolett.1c01420
Abstract: The nucleolus is a central hub for coordinating cellular stress responses during cancer development and treatment. Accurate identification of nucleolar stress response is crucially desired for nucleolus-based diagnostics and therapeutics but technically challenging due to… read more here.
Keywords: nucleolar stress; imaging nucleolar; protein mimicking; stress ... See more keywords
SmgGDS is a transient nucleolar protein that protects cells from nucleolar stress and promotes the cell cycle by regulating DREAM complex gene expression
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2017.280
Abstract: The chaperone protein and guanine nucleotide exchange factor SmgGDS (RAP1GDS1) is a key promoter of cancer cell proliferation and tumorigenesis. SmgGDS undergoes nucleocytoplasmic shuttling, suggesting that it has both cytoplasmic and nuclear functions that promote… read more here.
Keywords: smggds; nucleolar stress; protein; cell cycle ... See more keywords
p53 induces a survival transcriptional response after nucleolar stress.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular biology of the cell"
DOI: 10.1091/mbc.e21-05-0251
Abstract: Accumulating evidence indicate that increased ribosome biogenesis is a hallmark of cancer. It is well established that inhibition of any steps of ribosome biogenesis induces a nucleolar stress characterized by p53 activation and subsequent cell… read more here.
Keywords: ribosome biogenesis; stress; nucleolar stress; cell ... See more keywords
Nucleolar stress: Molecular mechanisms and related human diseases
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Science"
DOI: 10.1111/cas.15755
Abstract: Ribosome biogenesis in the nucleolus is an important process that consumes 80% of a cell's intracellular energy supply. Disruption of this process results in nucleolar stress, triggering the activation of molecular systems that respond to… read more here.
Keywords: stress molecular; stress; nucleolar stress; molecular mechanisms ... See more keywords
Nucleolar stress regulates stromal-epithelial transition via NPM1 during decidualization.
Sign Up to like & getrecommendations! Published in 2020 at "Reproduction"
DOI: 10.1530/rep-20-0051
Abstract: Embryo implantation and decidualization are crucial steps during early pregnancy. We recently showed that nucleolar stress is involved in embryo implantation. This study was to explore whether nucleolar stress participates in mouse and human decidualization.… read more here.
Keywords: epithelial transition; stromal epithelial; nucleolar stress; stress ... See more keywords
Nucleolar stress: Friend or foe in cardiac function?
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.1045455
Abstract: Studies in the past decades have uncovered an emerging role of the nucleolus in stress response and human disease progression. The disruption of ribosome biogenesis in the nucleolus causes aberrant nucleolar architecture and function, termed… read more here.
Keywords: stress; function; nucleolar stress; cardiac diseases ... See more keywords
Olaparib Induces RPL5/RPL11-Dependent p53 Activation via Nucleolar Stress
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.821366
Abstract: The poly (ADP-ribose) polymerase (PARP) inhibitor (PARPi) Olaparib is a widely used targeted therapy for a variety of solid tumors with homologous recombination deficiency (HRD) caused by mutation of BRCA1/2 or other DNA repair genes.… read more here.
Keywords: rpl5 rpl11; p53 activation; nucleolar stress; p53 ... See more keywords
uL3 Mediated Nucleolar Stress Pathway as a New Mechanism of Action of Antiproliferative G-quadruplex TBA Derivatives in Colon Cancer Cells
Sign Up to like & getrecommendations! Published in 2020 at "Biomolecules"
DOI: 10.3390/biom10040583
Abstract: The antiproliferative G-quadruplex aptamers are a promising and challenging subject in the framework of the anticancer therapeutic oligonucleotides research field. Although several antiproliferative G-quadruplex aptamers have been identified and proven to be effective on different… read more here.
Keywords: nucleolar stress; stress; antiproliferative quadruplex; mechanism action ... See more keywords
Nucleolar Stress Functions Upstream to Stimulate Expression of Autophagy Regulators
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13246220
Abstract: Simple Summary Ribosome biogenesis takes place in nucleoli and is essential for cellular survival and proliferation. In case this function is disturbed, either due to defects in regulatory factors or the structure of the nucleolus,… read more here.
Keywords: nucleolar stress; cancer; stress; ribosome biogenesis ... See more keywords
Association between Dysfunction of the Nucleolar Stress Response and Multidrug Resistance in Pediatric Acute Lymphoblastic Leukemia
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14205127
Abstract: Simple Summary Pediatric patients with B-cell precursor acute lymphoblastic leukemia (BCP-ALL) relapse or are refractory to chemotherapy despite the low frequency of TP53 mutations. The nucleolar stress response is one of the mechanisms that activate… read more here.
Keywords: bcp; stress response; nucleolar stress; leukemia ... See more keywords