Nucleophilic addition of amide anions to 1-methyl-5(6,7,8)-nitroquinolinium salts
Sign Up to like & getrecommendations! Published in 2019 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/s10593-019-02529-y
Abstract: The stable adducts, N-(1-methyl-5(6,7,8)-nitro-1,2-dihydroquinolin-2-yl)benzamides were synthesized for the first time by the action of amide anions of aromatic acids on the N-methyl salts of 5-, 6-, 7-, and 8-nitroquinolines in anhydrous MeCN. Oxidative dehydrogenation of… read more here.
Keywords: nucleophilic addition; anions methyl; nitroquinolinium salts; addition amide ... See more keywords
Investigation of a Sensing Strategy Based on a Nucleophilic Addition Reaction for Quantitative Detection of Bisulfite (HSO3−)
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Fluorescence"
DOI: 10.1007/s10895-020-02599-8
Abstract: A reaction-based sensor (NAS-1) showed a high affinity and sensitivity to HSO3- via a nucleophilic addition reaction in the aqueous media, giving dual signals from absorption and emission spectra. NAS-1 was successfully applied in RK13… read more here.
Keywords: nucleophilic addition; hso3; investigation sensing; reaction ... See more keywords
Discovery of chiral N-2'-aryletheryl-1'-alkoxy-ethyl substituted arylisoquinolones with anti-inflammatory activity from the nucleophilic addition reactions of the thiophenols and oxazolinium.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113583
Abstract: Herein we disclosed the novel nucleophilic addition reactions of the thiophenols and oxazolinium (DCZ0358) to produce N-2'-aryletheryl-1'-alkoxy-ethyl substituted arylisoquinolones. After evaluating the anti-inflammatory activity in vitro, 2d was found having significant anti-TNFα activity. Through the amplified… read more here.
Keywords: anti inflammatory; thiophenols oxazolinium; reactions thiophenols; nucleophilic addition ... See more keywords
Covalent bonding of aromatic amine daughter products of 2,4-dinitroanisole (DNAN) with model quinone compounds representing humus via nucleophilic addition.
Sign Up to like & getrecommendations! Published in 2020 at "Environmental pollution"
DOI: 10.1016/j.envpol.2020.115862
Abstract: 2,4-Dinitroanisole (DNAN) is a component of insensitive munitions (IM), which are replacing traditional explosives due to their improved safety. Incomplete IM combustion releases DNAN onto the soil, where it can leach into the subsurface with… read more here.
Keywords: addition; dinitroanisole dnan; nucleophilic addition; daughter products ... See more keywords
Markovnikov at Gold: Nucleophilic Addition to Alkenes at Au(III)
Sign Up to like & getrecommendations! Published in 2018 at "Organometallics"
DOI: 10.1021/acs.organomet.8b00218
Abstract: The reactivity of Au(OAcF)2(tpy) (1, OAcF = OCOCF3; tpy = 2-(p-tolyl)pyridine) toward a wide variety of different alkenes with various substitution patterns and different oxygen-based nucleophiles has been investigated. These reactions are two-step processes where… read more here.
Keywords: iii; addition; gold nucleophilic; addition alkenes ... See more keywords
Copper-Mediated Nucleophilic Addition/Cascade Cyclization of Aryl Diynes.
Sign Up to like & getrecommendations! Published in 2017 at "Organic letters"
DOI: 10.1021/acs.orglett.6b03787
Abstract: Treatment of diyne substrates with sulfinate salts under the action of copper(II) triflate results in a cascade cyclization reaction. The reaction involves nucleophilic addition of the sulfinate and formation of two new C-C bonds with… read more here.
Keywords: copper mediated; mediated nucleophilic; nucleophilic addition; cascade cyclization ... See more keywords
Ag(I)-Catalyzed Nucleophilic Addition and Friedel-Crafts Alkylation between α-Oxoketene Dithioacetals and Propargyl Carbonates.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.8b03180
Abstract: Silver-catalyzed nucleophilic addition and intramolecular Friedel-Crafts alkylation between α-oxoketene dithioacetals and tertiary propargylic carbonates have been realized. The reactions proceeded in moderate to good yields with broad substrate scope, providing a straightforward method for the… read more here.
Keywords: crafts alkylation; catalyzed nucleophilic; nucleophilic addition; alkylation oxoketene ... See more keywords
Nucleophilic Addition of Enolates to 1,4-Dehydrobenzene Diradicals Derived from Enediynes: Synthesis of Functionalized Aromatics
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c02916
Abstract: Alkylation of aromatics and formation of a new C–C bond is usually achieved by the electrophilic attack of an activated carbon species on an electron-rich aromatic ring. Herein, we report an alternative method for alkylation… read more here.
Keywords: addition enolates; nucleophilic addition; alkylation; derived enediynes ... See more keywords
Tandem nucleophilic addition-cycloaddition of arynes with α-iminoesters: two concurrent pathways to imidazolidines.
Sign Up to like & getrecommendations! Published in 2018 at "Chemical communications"
DOI: 10.1039/c8cc03806f
Abstract: The tandem nucleophilic addition-cycloaddition reaction has been developed for the synthesis of functionalized imidazolidine derivatives. A variety of α-iminoesters and aryne precursors were well tolerated under the mild reaction conditions. This asymmetric cycloaddition afforded imidazolidine… read more here.
Keywords: cycloaddition; nucleophilic addition; addition cycloaddition; two concurrent ... See more keywords
Stereoselective synthesis of fully substituted ethylenes via an Ag-catalyzed 1,6-nucleophilic addition/annulation cascade.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical communications"
DOI: 10.1039/c9cc10022a
Abstract: A catalytic 1,6-nucleophilic addition/annulation cascade was developed for the first time, and used to produce 27 hitherto unreported ethylene-linked 1-naphthol-imidazole pairs with generally good yields and complete stereoselectivity. An Ag2O-catalyzed reaction of yne-allenone esters with… read more here.
Keywords: fully substituted; annulation cascade; addition; synthesis fully ... See more keywords
Catalytic Enantioselective Synthesis of 4-Amino-1,2,3,4-tetrahydropyridine Derivatives from Intramolecular Nucleophilic Addition Reaction of Tertiary Enamides
Sign Up to like & getrecommendations! Published in 2018 at "Synlett"
DOI: 10.1055/s-0037-1610384
Abstract: A general and efficient method for the synthesis of highly enantiopure 4-amino-1,2,3,4-tetradydropyridine derivatives based on chiral phosphoric acid catalyzed intramolecular nucleophilic addition of tertiary enamides to imines has been developed. We have also demonstrated a… read more here.
Keywords: amino; tertiary enamides; nucleophilic addition; intramolecular nucleophilic ... See more keywords