Instability at the Electrode/Electrolyte Interface Induced by Hard Cation Chelation and Nucleophilic Attack
Sign Up to like & getrecommendations! Published in 2017 at "Chemistry of Materials"
DOI: 10.1021/acs.chemmater.7b03404
Abstract: Electrochemistry is necessarily a science of interfacial processes, and understanding electrode/electrolyte interfaces is essential to controlling electrochemical performance and stability. Undesirable interfacial interactions hinder discovery and development of rational materials combinations. By example, we examine… read more here.
Keywords: chelation; instability; nucleophilic attack; chemistry ... See more keywords
In vitro Biotransformation of the Nrf2 activator Bardoxolone: Formation of an Epoxide Metabolite that Undergoes Two Novel Glutathione-Mediated Metabolic Pathways; Epoxide Reduction and Oxidative Elimination of Nitrile Moiety.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.9b00289
Abstract: Metabolism of bardoxolone methyl (BARD-Me), an oleanolic acid derivative, and its epoxide metabolite was studied in different in vitro systems. BARD-Me also undergoes glutathione (GSH)-adduct formation via direct nucleophilic attack at the β-carbon of the… read more here.
Keywords: elimination nitrile; nucleophilic attack; oxidative elimination; epoxide metabolite ... See more keywords
Gold-Catalyzed Oxidative Cyclization Involving Nucleophilic Attack to the Keto Group of α,α'-Dioxo Gold Carbene and 1,2-Alkynyl Migration: Synthesis of Furan-3-carboxylates.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c02389
Abstract: A multicomponent strategy for the synthesis of functionalized furan-3-carboxylates based on gold-catalyzed oxidative cyclization of diynones with alcohols or water has been developed. Mechanistic studies revealed that a rare nucleophilic attack to the carbonyl group… read more here.
Keywords: nucleophilic attack; group; furan carboxylates; gold catalyzed ... See more keywords
Probing the Free Energy Landscape of Organophotoredox-Catalyzed Anti-Markovnikov Hydrofunctionalization of Alkenes.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c07807
Abstract: Experimental 13C kinetic isotope effects (KIEs) provide unprecedented mechanistic insight into three intermolecular anti-Markovnikov alkene hydrofunctionalization reactions─hydroesterification, hydroamination, and hydroetherification─enabled by organophotoredox catalysis. All three reactions are found to proceed via initial oxidation of the… read more here.
Keywords: hydrofunctionalization; anti markovnikov; nucleophilic attack; rate limiting ... See more keywords
Substrate-dependent Mechanism for Nickel-catalyzed N-allylation with Allylic Alcohols: Nucleophilic Attack vs Reductive Elimination
Sign Up to like & getrecommendations! Published in 2023 at "Organic Chemistry Frontiers"
DOI: 10.1039/d3qo00301a
Abstract: Transition metal catalyzed amination of allylic alcohols via π-allylmetal is generally accepted to undergo a nucleophilic attack mechanism. However, we herein found the possibility of the competition between the reductive... read more here.
Keywords: allylic alcohols; substrate dependent; nucleophilic attack; mechanism ... See more keywords
New Insight into the Chloroacetanilide Herbicide Degradation Mechanism through a Nucleophilic Attack of Hydrogen Sulfide
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms19102864
Abstract: The nucleophilic attack of hydrogen sulfide (HS−) on six different chloroacetanilide herbicides was evaluated theoretically using the dispersion-corrected hybrid functional wB97XD and the 6-311++G(2d,2p) Pople basis sets. The six evaluated substrates were propachlor (A), alachlor… read more here.
Keywords: mechanism; nucleophilic attack; kcal mol; reaction ... See more keywords