Unexpected intramolecular nucleophilic cyclization of ureidoacetamide: A novel route towards the synthesis of 2,4,5-trisubsituted oxazoles
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2019.05.028
Abstract: Abstract A variety of N, 2-diaryl-2-ureidoacetamide prepared from the condensation of N-aryl-α-aminoamide with potassium cyanate (KOCN) undergo efficient Hendrickson’s reagent-mediated nucleophilic cyclization to afford 2,5-diamine-4-aryloxazoles. The two-step synthesis provides seven target products in yields of… read more here.
Keywords: synthesis; nucleophilic cyclization; unexpected intramolecular; cyclization ... See more keywords
Silver-Catalyzed Direct Nucleophilic Cyclization: Enantioselective De Novo Synthesis of C-C Axially Chiral 2-Arylindoles.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.2c04234
Abstract: Atropisomeric indoles widely exist in natural products, pharmaceuticals, functional materials, and catalysts for their featured biological activities, photoelectric properties, and catalytic activities, while facile and de novo construction of this motif remains underexplored. Herein, we… read more here.
Keywords: enantioselective novo; nucleophilic cyclization; chiral arylindoles; catalyzed direct ... See more keywords