A Curious Novel Combination of Nucleophosmin (NPM1) Gene Mutations Leading to Aberrant Cytoplasmic Dislocation of NPM1 in Acute Myeloid Leukemia (AML)
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DOI: 10.3390/genes12091426
Abstract: Nucleophosmin (NPM1) mutations occurring in acute myeloid leukemia (AML) (about 50 so far identified) cluster almost exclusively in exon 12 and lead to common changes at the NPM1 mutants C-terminus, i.e., loss of tryptophans 288… read more here.
Keywords: myeloid leukemia; leukemia aml; acute myeloid; nucleophosmin npm1 ... See more keywords
The Role of Nucleophosmin 1 (NPM1) Mutation in the Diagnosis and Management of Myeloid Neoplasms
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DOI: 10.3390/life12010109
Abstract: Nucleophosmin (NPM1) is a multifunctional protein with both proliferative and growth-suppressive roles in the cell. In humans, NPM1 is involved in tumorigenesis via chromosomal translocations, deletions, or mutation. Acute myeloid leukemia (AML) with mutated NPM1,… read more here.
Keywords: role; nucleophosmin npm1; myeloid; myeloid neoplasms ... See more keywords