Antibacterial Nucleoside-Analog Inhibitor of Bacterial RNA Polymerase
Sign Up to like & getrecommendations! Published in 2017 at "Cell"
DOI: 10.1016/j.cell.2017.05.042
Abstract: Drug-resistant bacterial pathogens pose an urgent public-health crisis. Here, we report the discovery, from microbial-extract screening, of a nucleoside-analog inhibitor that inhibits bacterial RNA polymerase (RNAP) and exhibits antibacterial activity against drug-resistant bacterial pathogens: pseudouridimycin (PUM).… read more here.
Keywords: inhibitor; bacterial rna; rna polymerase; nucleoside analog ... See more keywords
Alanine aminotransferase levels as therapeutic targets after nucleotide/nucleoside analog therapy in patient with chronic hepatitis B
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology Research"
DOI: 10.1111/hepr.13839
Abstract: Alanine aminotransferase (ALT) is a criterion for the introduction of nucleotide/nucleoside analog (NA), and ALT levels are decreased by NA treatment. However, the association between post‐treatment ALT levels and hepatocellular carcinoma (HCC) risk remains unclear.… read more here.
Keywords: nucleoside analog; alanine aminotransferase; aminotransferase levels; levels therapeutic ... See more keywords
The nucleoside analog 4′-fluorouridine suppresses the replication of multiple enteroviruses by targeting 3D polymerase
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DOI: 10.1128/aac.00054-24
Abstract: ABSTRACT Human enteroviruses are the major pathogens causing hand-foot-and-mouth disease in infants and young children throughout the world, and infection with enterovirus is also associated with severe complications, such as aseptic meningitis and myocarditis. However,… read more here.
Keywords: nucleoside analog; replication; polymerase; fluorouridine suppresses ... See more keywords
Abstract IA20: PET imaging of the immune system using new nucleoside analog probes
Sign Up to like & getrecommendations! Published in 2017 at "Cancer immunology research"
DOI: 10.1158/2326-6074.tumimm16-ia20
Abstract: Similar to other major metabolic networks, nucleotide metabolism consists of redundant and convergent biosynthetic pathways. Thus, nucleotides can be produced both de novo, from glucose and amino acids, and by salvage pathways, via scavenging and… read more here.
Keywords: pet; imaging immune; pet imaging; nucleoside analog ... See more keywords
Determining RNA Natural Modifications and Nucleoside Analog-Labeled Sites by a Chemical/Enzyme-Induced Base Mutation Principle
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DOI: 10.3390/molecules28041517
Abstract: The natural chemical modifications of messenger RNA (mRNA) in living organisms have shown essential roles in both physiology and pathology. The mapping of mRNA modifications is critical for interpreting their biological functions. In another dimension,… read more here.
Keywords: nucleoside analog; analog labeled; modifications nucleoside; rna natural ... See more keywords