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Published in 2017 at "Cell"
DOI: 10.1016/j.cell.2017.05.042
Abstract: Drug-resistant bacterial pathogens pose an urgent public-health crisis. Here, we report the discovery, from microbial-extract screening, of a nucleoside-analog inhibitor that inhibits bacterial RNA polymerase (RNAP) and exhibits antibacterial activity againstĀ drug-resistant bacterial pathogens: pseudouridimycin (PUM).…
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Keywords:
inhibitor;
bacterial rna;
rna polymerase;
nucleoside analog ... See more keywords
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Published in 2022 at "Hepatology Research"
DOI: 10.1111/hepr.13839
Abstract: Alanine aminotransferase (ALT) is a criterion for the introduction of nucleotide/nucleoside analog (NA), and ALT levels are decreased by NA treatment. However, the association between postātreatment ALT levels and hepatocellular carcinoma (HCC) risk remains unclear.…
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Keywords:
nucleoside analog;
alanine aminotransferase;
aminotransferase levels;
levels therapeutic ... See more keywords
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Published in 2017 at "Cancer immunology research"
DOI: 10.1158/2326-6074.tumimm16-ia20
Abstract: Similar to other major metabolic networks, nucleotide metabolism consists of redundant and convergent biosynthetic pathways. Thus, nucleotides can be produced both de novo, from glucose and amino acids, and by salvage pathways, via scavenging and…
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Keywords:
pet;
imaging immune;
pet imaging;
nucleoside analog ... See more keywords
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Published in 2023 at "Molecules"
DOI: 10.3390/molecules28041517
Abstract: The natural chemical modifications of messenger RNA (mRNA) in living organisms have shown essential roles in both physiology and pathology. The mapping of mRNA modifications is critical for interpreting their biological functions. In another dimension,…
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Keywords:
nucleoside analog;
analog labeled;
modifications nucleoside;
rna natural ... See more keywords