Development of Fluorophosphoramidate as a Biocompatibly Transformable Functional Group and its Application as a Phosphate Prodrug for Nucleoside Analogs
Sign Up to like & getrecommendations! Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202200188
Abstract: Synthetic phosphate‐derived functional groups are important for controlling the function of bioactive molecules in vivo. Herein we describe the development of a new type of biocompatible phosphate analog, a fluorophosphoramidate (FPA) functional group that has characteristic… read more here.
Keywords: prodrug nucleoside; group; amino group; nucleoside analogs ... See more keywords
Nucleoside analogs as potential antiviral agents for dengue virus infections
Sign Up to like & getrecommendations! Published in 2017 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-017-1863-4
Abstract: Dengue virus is the causative agent of dengue fever and also the most prevalent mosquito borne viral pathogen. Up until now, treatments for dengue fever rely mainly on intensive supportive therapies. This study aimed to… read more here.
Keywords: dengue virus; analogs potential; potential antiviral; nucleoside analogs ... See more keywords
3141 – LEUKEMIA-ASSOCIATED MUTATIONS IN DNMT3A MEDIATE SENSITIVITY TO REPLICATION STRESS INDUCED BY NUCLEOSIDE ANALOGS
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Hematology"
DOI: 10.1016/j.exphem.2020.09.148
Abstract: Acute myeloid leukemia is characterized by recurrent somatic mutations in epigenetic modifier genes like DNA methyltransferase 3A (DNMT3A). Mutations in DNMT3A are commonly seen in older patients who are unfit for intensive chemotherapy and thus… read more here.
Keywords: leukemia; replication stress; mutations dnmt3a; replication ... See more keywords
A short de novo synthesis of nucleoside analogs
Sign Up to like & getrecommendations! Published in 2020 at "Science"
DOI: 10.1126/science.abb3231
Abstract: Short path to a complex ring Nucleotide analogs are valuable tools and therapeutics because of their ability to interfere with processes such as DNA synthesis, which are vital to rapidly dividing cells and replicating viruses.… read more here.
Keywords: novo synthesis; nucleoside analogs; reaction; short novo ... See more keywords
Unifying the synthesis of nucleoside analogs
Sign Up to like & getrecommendations! Published in 2020 at "Science"
DOI: 10.1126/science.abd1283
Abstract: A short, versatile synthetic pathway transforms achiral reactants into nucleoside analogs Nucleosides, the building blocks of DNA and RNA, typically contain a ribose sugar attached to a nucleobase. Structurally modified nucleoside analogs can disrupt the… read more here.
Keywords: nucleoside analogs; unifying synthesis; virus; synthesis ... See more keywords
Structural Insights Into Tautomeric Dynamics in Nucleic Acids and in Antiviral Nucleoside Analogs
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2021.823253
Abstract: DNA (2′-deoxyribonucleic acid) and RNA (ribonucleic acid) play diverse functional roles in biology and disease. Despite being comprised primarily of only four cognate nucleobases, nucleic acids can adopt complex three-dimensional structures, and RNA in particular,… read more here.
Keywords: antiviral nucleoside; structural insights; minor tautomers; tautomeric dynamics ... See more keywords
Nucleoside Analogs That Inhibit SARS-CoV-2 Replication by Blocking Interaction of Virus Polymerase with RNA
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24043361
Abstract: The SARS-CoV-2 betacoronavirus pandemic has claimed more than 6.5 million lives and, despite the development and use of COVID-19 vaccines, remains a major global public health problem. The development of specific drugs for the treatment… read more here.
Keywords: polymerase rna; nucleoside analogs; virus; sars cov ... See more keywords
Alicyclic β- and γ-Amino Acids: Useful Scaffolds for the Stereocontrolled Access to Amino Acid-Based Carbocyclic Nucleoside Analogs
Sign Up to like & getrecommendations! Published in 2019 at "Molecules"
DOI: 10.3390/molecules24010161
Abstract: Stereocontrolled synthesis of some amino acid-based carbocyclic nucleoside analogs containing ring C=C bond has been performed on β- and γ-lactam basis. Key steps were N-arylation of readily available β- or γ-lactam-derived amino ester isomers and… read more here.
Keywords: based carbocyclic; acid based; amino acid; nucleoside analogs ... See more keywords