Flaviviridae viruses use a common molecular mechanism to escape nucleoside analogue inhibitors.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.03.068
Abstract: The RNA-dependent RNA polymerases of Flaviviridae viruses are crucial for replication. The Flaviviridae polymerase is organized into structural motifs (A-G), with motifs F, A, C and E containing interrogating, priming and catalytic substrate-interacting sites. Modified… read more here.
Keywords: flaviviridae viruses; analogue inhibitors; threonine; nucleoside analogue ... See more keywords
Nucleoside analogue activators of cyclic AMP-independent protein kinase A of Trypanosoma
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-09338-z
Abstract: Protein kinase A (PKA), the main effector of cAMP in eukaryotes, is a paradigm for the mechanisms of ligand-dependent and allosteric regulation in signalling. Here we report the orthologous but cAMP-independent PKA of the protozoan… read more here.
Keywords: camp; cnb domains; pka; protein kinase ... See more keywords
Crystal structure and Hirshfeld surface analysis of the anhydrous form of the nucleoside analogue entecavir.
Sign Up to like & getrecommendations! Published in 2018 at "Acta crystallographica. Section C, Structural chemistry"
DOI: 10.1107/s2053229618002528
Abstract: The nucleoside analogue entecavir {systematic name: 2-amino-9-[(1S,3R,4S)-4-hydroxy-3-hydroxymethyl-2-methylenecyclopentyl]-1,9-dihydro-6H-purin-6-one}, C12H15N5O3, is an antihepatitis B virus drug that has been approved in the US, EU and several countries worldwide. We report here the single-crystal structure of the anhydrous… read more here.
Keywords: crystal structure; hirshfeld surface; form; analogue entecavir ... See more keywords
A Pseudouridine Isoxazolidinyl Nucleoside Analogue Structural Analysis: A Morphological Approach
Sign Up to like & getrecommendations! Published in 2018 at "Molecules"
DOI: 10.3390/molecules23123381
Abstract: An in silico study has been conducted upon (3′RS,5′SR)-5-[2′-benzyl-5′-hydroxymethyl-1′,2′-isoxazolidin-3′-yl]uracil through a molecular dynamics/docking approach that highlights its potential inhibitory activity upon the wild-type pseudouridine 5′-monophosphate glycosidase. The crystal structure of this compound has been solved… read more here.
Keywords: pseudouridine; pseudouridine isoxazolidinyl; isoxazolidinyl nucleoside; approach ... See more keywords
Rapid Resolution of Non-Effusive Feline Infectious Peritonitis Uveitis with an Oral Adenosine Nucleoside Analogue and Feline Interferon Omega
Sign Up to like & getrecommendations! Published in 2020 at "Viruses"
DOI: 10.3390/v12111216
Abstract: This is the first report of a successful treatment of a non-effusive feline infectious peritonitis (FIP) uveitis case using an oral adenosine nucleoside analogue drug and feline interferon omega, and alpha-1 acid glycoprotein (AGP) as… read more here.
Keywords: feline interferon; non effusive; adenosine nucleoside; feline ... See more keywords