Nucleic Acids as a Nature‐Inspired Scaffold for Macromolecular Prodrugs of Nucleoside Analogues
Sign Up to like & getrecommendations! Published in 2019 at "Advanced Science"
DOI: 10.1002/advs.201802095
Abstract: Abstract Macromolecular prodrugs (MP) built on the natural phosphodiester and deoxyribose backbone are developed using marketed antiviral nucleoside analogues. These MP are synthesized using automated synthesis, have defined molecular composition, and have a natural mechanism… read more here.
Keywords: acids nature; nucleic acids; nature inspired; nucleoside analogues ... See more keywords
Chemical Approaches to Carbocyclic Nucleosides.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical record"
DOI: 10.1002/tcr.202100307
Abstract: Nucleoside analogues are at the forefront of antiviral therapy for last decades. To circumvent some of their limitations, based on their metabolism, and in order to improve their anti-viral potency and selectivity, several families of… read more here.
Keywords: chemistry; carbocyclic nucleosides; approaches carbocyclic; nucleoside analogues ... See more keywords
The Different Effects of Nucleotide and Nucleoside Analogues on the Prognosis of HBV-Related HCC After Curative Resection
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Gastrointestinal Surgery"
DOI: 10.1007/s11605-020-04633-3
Abstract: Background Postoperative oral antiviral treatment with nucleoside or nucleotide analogues can suppress viral replication and reduce tumour recurrence for patients with hepatitis b virus–related hepatocellular carcinoma (HBV-related HCC) after curative resection. However, the superior antiviral… read more here.
Keywords: resection; hbv related; related hcc; nucleoside analogues ... See more keywords
Antiviral effects of selected nucleoside analogues against human parechoviruses A1 and A3.
Sign Up to like & getrecommendations! Published in 2019 at "Antiviral research"
DOI: 10.1016/j.antiviral.2018.12.009
Abstract: Parechoviruses A (HPeV, Picornaviridae) are neglected human pathogens that cause sepsis-like illness and severe neurological complications in infants. There are no antivirals available for the treatment of HPeV infections. We here report on cell-based assays… read more here.
Keywords: antiviral effects; effects selected; analogues human; selected nucleoside ... See more keywords
Interaction Of 5-Substituted Pyrimidine Nucleoside Analogues And M.Tuberculosis: A View Through An Electron Microscope.
Sign Up to like & getrecommendations! Published in 2020 at "Biochimie"
DOI: 10.1016/j.biochi.2020.03.004
Abstract: The data of transmission electron microscopy (TEM) on morphology of M. tuberculosis H37Rv bacterial cells treated with four analogues of pyrimidine nucleosides with different substituents at 5 position of base are presented. We showed that… read more here.
Keywords: interaction substituted; substituted pyrimidine; tuberculosis; pyrimidine nucleoside ... See more keywords
Synthesis of het(aryl) imidazole C-nucleoside analogues by CoFe2O4 NPs catalyzed muti-component coupling reaction.
Sign Up to like & getrecommendations! Published in 2019 at "Carbohydrate research"
DOI: 10.1016/j.carres.2019.03.013
Abstract: A general synthesis of hetaryl and aryl C-4(5) linked imidazole C-nucleoside analogues has been developed by the reaction of sugar alkynes with het(aryl) iodides, KMnO4/TBAB oxidation and CoFe2O4 NPs catalyzed muti-component coupling of the corresponding… read more here.
Keywords: catalyzed muti; imidazole nucleoside; cofe2o4 nps; het aryl ... See more keywords
Synthesis, characterization and biological evaluation of purine nucleoside analogues
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2017.09.041
Abstract: We present a convenient route for the synthesis of C6-amino-C5’-N-cyclopropyl carboxamido-C2-alkynylated purine nucleoside analogues 11a-g via Sonogashira coupling reaction. The nine step synthesis is easy to perform, employing commercially available reagents. Compound 9 is used… read more here.
Keywords: purine nucleoside; characterization biological; biological evaluation; analogues 11a ... See more keywords
Discovery of pyrrolo[2,3-b]pyridine (1,7-dideazapurine) nucleoside analogues as anti-Trypanosoma cruzi agents.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.9b01275
Abstract: Trypanosoma cruzi is the causative pathogen of Chagas disease and the main culprit for cardiac-related mortality in Latin-America triggered by an infective agent. Uncapable of synthesizing purines de novo, this parasite depends on acquisition and… read more here.
Keywords: pyridine dideazapurine; pyrrolo pyridine; nucleoside analogues; trypanosoma cruzi ... See more keywords
Synthesis of C6-Substituted Purine Nucleoside Analogues via Late-Stage Photoredox/Nickel Dual Catalytic Cross-Coupling.
Sign Up to like & getrecommendations! Published in 2021 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.0c00673
Abstract: Nucleoside analogues have been and continue to be extremely important compounds in drug discovery. Despite the significant effort dedicated to their synthesis, medicinal chemistry campaigns around these structures are often hampered by synthetic challenges. We… read more here.
Keywords: photoredox nickel; medicinal chemistry; chemistry; nucleoside analogues ... See more keywords
Aptamers Entirely Built from Therapeutic Nucleoside Analogues for Targeted Cancer Therapy.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c09574
Abstract: Owing to the specific and high binding affinity of aptamers to their targets, aptamer-drug conjugates (ApDCs) have emerged as a promising drug delivery system for targeted cancer therapy. However, in a conventional ApDC, the aptamer… read more here.
Keywords: targeted cancer; nucleoside analogues; cancer therapy; drug ... See more keywords
Design and synthesis of purine nucleoside analogues for the formation of stable anti-parallel-type triplex DNA with duplex DNA bearing the 5mCG base pair
Sign Up to like & getrecommendations! Published in 2021 at "RSC Advances"
DOI: 10.1039/d1ra02831f
Abstract: Ryotaro Notomi, Lei Wang, Shigeki Sasaki* and Yosuke Taniguchi *a We herein demonstrated for the first time the direct recognition of duplex DNA bearing the 5-methyl-20deoxycytosine and 20-deoxyguanosine base pair by triplex DNA formation. Triplex-forming… read more here.
Keywords: dna; nucleoside analogues; base pair; triplex dna ... See more keywords