Synthesis of a 3′-C-ethynyl-β-d-ribofuranose purine nucleoside library: Discovery of C7-deazapurine analogs as potent antiproliferative nucleosides
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DOI: 10.1016/j.ejmech.2018.07.062
Abstract: Abstract A focused nucleoside library was constructed around a 3′-C-ethynyl-d-ribofuranose sugar scaffold, which was coupled to variously modified purine nucleobases. The resulting nucleosides were probed for their ability to inhibit tumor cell proliferation, as well… read more here.
Keywords: deazapurine; potent antiproliferative; nucleoside library; ethynyl ribofuranose ... See more keywords