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Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c03252
Abstract: 3-(2-Deoxy-β-d-erythropentofuranosyl)pyrimido[1,2-a]purin-10(3H)-one (M1dG) is an endogenous DNA adduct in bacterial and mammalian cells that could be explored as a biomarker for oxidative stress. Nonetheless, the lack of an efficient methodology for the preparation of M1dG hampers…
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Keywords:
analogues cyclization;
guanine base;
nucleoside nucleotide;
nucleotide analogues ... See more keywords
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Published in 2020 at "AIDS"
DOI: 10.1097/qad.0000000000002580
Abstract: : Exposure of infants to antiretroviral drugs for prevention of mother-to-child transmission can induce resistance to nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs). Data from nine national surveys of pretreatment drug resistance in children newly diagnosed with…
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Keywords:
nucleoside nucleotide;
nucleotide reverse;
treatment;
resistance ... See more keywords
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Published in 2017 at "Current pharmaceutical design"
DOI: 10.2174/1381612823666171011104158
Abstract: BACKGROUND Modified nucleoside and nucleotide analogs are now the cornerstone of antiviral and anticancer chemotherapies. However, these compounds are not active on their own and need, after entering the cell, to be metabolized to their…
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Keywords:
nucleosides nucleotides;
nucleotides prodrugs;
nucleoside nucleotide;
metabolism nucleosides ... See more keywords