Evaluation of ODE‐Bn‐PMEG, an acyclic nucleoside phosphonate prodrug, as an antiviral against productive HPV infection in 3D organotypic epithelial cultures
Sign Up to like & getrecommendations! Published in 2018 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2017.12.013
Abstract: HighlightsODE‐Bn‐PMEG abolishes human papillomavirus productive infection in 3D cultures of primary human keratinocytes (PHKs).Incorporation of activated ODE‐Bn‐PMEG into replicating DNA causes DNA breaks and abolishes viral activities.ODE‐Bn‐PMEG induces apoptosis selectively in HPV‐infected, differentiated keratinocytes while… read more here.
Keywords: acyclic nucleoside; ode pmeg; nucleoside phosphonate; infection ... See more keywords