Acyclic Nucleoside Phosphonates Containing 9‐Deazahypoxanthine and a Five‐Membered Heterocycle as Selective Inhibitors of Plasmodial 6‐Oxopurine Phosphoribosyltransferases
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DOI: 10.1002/cmdc.201700293
Abstract: Acyclic nucleoside phosphonates (ANPs) are an important class of therapeutic drugs that act as antiviral agents by inhibiting viral DNA polymerases and reverse transcriptases. ANPs containing a 6‐oxopurine unit instead of a 6‐aminopurine or pyrimidine… read more here.
Keywords: nucleoside phosphonates; membered heterocycle; five membered; deazahypoxanthine five ... See more keywords
Synthesis and Antiviral Evaluation of 3′‐Fluoro‐4′‐modified‐5′‐norcarbocyclic Nucleoside Phosphonates
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DOI: 10.1002/cmdc.201800804
Abstract: The synthesis and anti‐HIV evaluation of hitherto unknown 3′‐fluoro‐5′‐norcarbocyclic nucleoside phosphonates bearing adenine with modifications at the 4′ position (ethynyl, vinyl, ethyl, hydroxymethyl) is described. One of the synthesized compounds was found to be an… read more here.
Keywords: norcarbocyclic nucleoside; nucleoside phosphonates; antiviral evaluation; evaluation fluoro ... See more keywords
N2' -Branched Acyclic Nucleoside Phosphonates Containing 9-Deazahypoxanthine as Inhibitors of Plasmodium falciparum 6-Oxopurine Phosphoribosyltransferase.
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DOI: 10.1002/cmdc.202300211
Abstract: Twelve N2'-branched acyclic nucleoside phosphonates and bisphosphonates were synthesized as potential inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPRT), the key enzyme in the purine salvage pathway for production of purine nucleotides. The chemical structures were… read more here.
Keywords: plasmodium falciparum; nucleoside phosphonates; branched acyclic; acyclic nucleoside ... See more keywords
C1'-Branched acyclic nucleoside phosphonates mimicking adenosine monophosphate: Potent inhibitors of Trypanosoma brucei adenine phosphoribosyltransferase.
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DOI: 10.1016/j.ejmech.2021.113798
Abstract: Some pathogens, including parasites of the genus Trypanosoma causing Human and Animal African Trypanosomiases, cannot synthesize purines de novo and they entirely rely on the purine salvage pathway (PSP) for their nucleotide generation. Thus, their… read more here.
Keywords: nucleoside phosphonates; brucei adenine; trypanosoma brucei; adenosine monophosphate ... See more keywords
Synthesis and Antiviral Evaluation of 3′-Fluoro-5′-norcarbocyclic Nucleoside Phosphonates Bearing Uracil and Cytosine as Potential Antiviral Agents
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DOI: 10.3390/molecules25163708
Abstract: Carbocyclic nucleoside analogues are an essential class of antiviral agents and are commonly used in the treatment of viral diseases (hepatitis B, AIDS). Recently, we reported the racemic synthesis and the anti-human immunodeficiency virus activities… read more here.
Keywords: synthesis antiviral; norcarbocyclic nucleoside; nucleoside phosphonates; antiviral agents ... See more keywords