Biocatalytic synthesis of seleno-, thio- and chloro-nucleobase modified nucleosides by thermostable nucleoside phosphorylases
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DOI: 10.1016/j.catcom.2018.12.004
Abstract: Abstract Selenium-containing nucleosides are the building blocks of the Se-nucleic acids useful for structure-and-function study, drug discovery and for targeting nucleic acids and their protein complexes. However, chemical synthesis of these Se-containing nucleosides is labor-intensive… read more here.
Keywords: modified nucleosides; biocatalytic synthesis; synthesis; thermostable nucleoside ... See more keywords
Comparative Analysis of Enzymatic Transglycosylation Using E. coli Nucleoside Phosphorylases: A Synthetic Concept for the Preparation of Purine Modified 2′-Deoxyribonucleosides from Ribonucleosides
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DOI: 10.3390/ijms23052795
Abstract: A comparative analysis of the transglycosylation conditions catalyzed by E. coli nucleoside phosphorylases, leading to the formation of 2′-deoxynucleosides, was performed. We demonstrated that maximal yields of 2′-deoxynucleosides, especially modified, can be achieved under small… read more here.
Keywords: comparative analysis; purine modified; nucleoside phosphorylases; coli nucleoside ... See more keywords