Fluoride Pharmacokinetics in Urine and Plasma Following Multiple Doses of MK-8507, an Investigational, Oral, Once-Weekly Non-Nucleoside Reverse Transcriptase Inhibitor.
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DOI: 10.1002/jcph.1957
Abstract: MK-8507 is an investigational human immunodeficiency virus-1 (HIV-1) non-nucleoside reverse transcriptase inhibitor being developed for the treatment of HIV-1 infection. MK-8507 contains two trifluoromethyl groups that may result in fluoride release through metabolism, but the… read more here.
Keywords: non; nucleoside reverse; 8507 investigational; non nucleoside ... See more keywords
Nucleoside reverse transcriptase inhibitors (NRTIs) induce proinflammatory cytokines in the CNS via Wnt5a signaling
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DOI: 10.1038/s41598-017-03446-w
Abstract: HAART is very effective in suppressing HIV-1 replication in patients. However, patients staying on long-term HAART still develop various HIV-associated neurological disorders, even when the viral load is low. The underlying pathogenic mechanisms are largely… read more here.
Keywords: wnt5a; proinflammatory cytokines; nucleoside reverse; wnt5a signaling ... See more keywords
Discovery of piperidine-substituted thiazolo[5,4-d]pyrimidine derivatives as potent and orally bioavailable HIV-1 non-nucleoside reverse transcriptase inhibitors
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DOI: 10.1038/s42004-019-0174-8
Abstract: HIV-1 reverse transcriptase offers a key target for antiviral therapy. However, the rapid emergence of drug-resistant mutations in reverse transcriptase as well as the poor pharmacokinetic properties of HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) limits… read more here.
Keywords: transcriptase inhibitors; nucleoside reverse; reverse; non nucleoside ... See more keywords
A Concise Analytical Profile of Efavirenz: Analytical Methodologies.
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DOI: 10.1080/10408347.2021.1895711
Abstract: Non-nucleoside reverse transcriptase inhibitors are the prime members of antiretroviral therapy that are presently employed for the management of the human immunodeficiency virus. It uses an enzyme i.e., reverse transcriptase to convert its ribonucleic acid… read more here.
Keywords: antiretroviral therapy; nucleoside reverse; reverse; non nucleoside ... See more keywords
Ritonavir-Boosted Darunavir Plus Two Nucleoside Reverse Transcriptase Inhibitors versus Other Regimens for Initial Antiretroviral Therapy for People with HIV Infection: A Systematic Review
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DOI: 10.1155/2017/2345617
Abstract: Background Darunavir is a second-generation protease-inhibitor used with ritonavir (DRV/r) and two nucleoside reverse-transcriptase inhibitors as an option in first-line antiretroviral treatment (ART). Methods We systematically reviewed randomized controlled trials (RCTs) of DRV/r versus other… read more here.
Keywords: transcriptase inhibitors; ritonavir boosted; nucleoside reverse; ritonavir ... See more keywords
Efficacy of second-line dolutegravir plus 2 nucleoside reverse transcriptase inhibitors by baseline nucleoside reverse transcriptase inhibitor resistance and nucleoside reverse transcriptase inhibitor use in the DAWNING study
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DOI: 10.1177/13596535221077487
Abstract: Background In the DAWNING study, dolutegravir + 2 nucleoside reverse transcriptase inhibitors (NRTIs) demonstrated superior efficacy at Week 48 and a favourable safety profile compared with lopinavir/ritonavir + 2 NRTIs in adults with HIV-1 failing… read more here.
Keywords: nucleoside reverse; reverse transcriptase; transcriptase inhibitor;
Multicenter study of skin rashes and hepatotoxicity in antiretroviral-naïve HIV-positive patients receiving non-nucleoside reverse-transcriptase inhibitor plus nucleoside reverse-transcriptase inhibitors in Taiwan
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DOI: 10.1371/journal.pone.0171596
Abstract: Objectives Two nucleos(t)ide reverse-transcriptase inhibitors (NRTIs) plus 1 non-NRTI (nNRTI) remain the preferred or alternative combination antiretroviral therapy (cART) for antiretroviral-naive HIV-positive patients in Taiwan. The three most commonly used nNRTIs are nevirapine (NVP), efavirenz… read more here.
Keywords: nucleoside reverse; hepatotoxicity; reverse transcriptase; hiv positive ... See more keywords
Development of novel S-N3-DABO derivatives as potent non-nucleoside reverse transcriptase inhibitors with improved potency and selectivity.
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DOI: 10.2139/ssrn.4276520
Abstract: Following on our initial discovery of S-CN-DABOs as non-nucleoside reverse transcriptase inhibitors (NNRTIs), a series of novel S-N3-DABO derivatives F1-F31 were developed by substituting the cyano group of S-CN-DABOs with azide group. Some of these… read more here.
Keywords: potency; reverse transcriptase; reverse; nucleoside reverse ... See more keywords
In vitro effect of some nucleoside reverse transcriptase inhibitors against HSV-1 replication.
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DOI: 10.26355/eurrev_202002_20204
Abstract: OBJECTIVE The current study was designed to investigate the effects of some nucleoside reverse transcriptase inhibitors (NRTIs) on HSV-1 infection. MATERIALS AND METHODS Initially, the SwissTargetPrediction server was used to predict the interactions between HSV-1… read more here.
Keywords: transcriptase inhibitors; nucleoside reverse; reverse transcriptase; replication ... See more keywords
Synthesis and molecular docking studies of quinoline derivatives as HIV non-nucleoside reverse transcriptase inhibitors
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DOI: 10.3906/kim-2004-14
Abstract: Quinoline moiety is an important scaffold in the field of drug discovery and drug development, with a wide range of pharmacological activities. Quinoline derivatives are potent inhibitors for reverse transcriptase, which is responsible for the… read more here.
Keywords: transcriptase inhibitors; nucleoside reverse; non nucleoside; reverse transcriptase ... See more keywords