Anti-HIV-active Nucleoside Triphosphate Prodrugs.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c00271
Abstract: We disclose a study on nucleoside triphosphate (NTP) analogues in which the γ-phosphate is covalently modified by F8butwo different biodegradable masking units and d4T as nucleoside analogue that enable the delivery of d4TTP with high… read more here.
Keywords: active nucleoside; hiv active; chemistry; triphosphate prodrugs ... See more keywords
Molecular dynamic simulations reveal structural insights into substrate and inhibitor binding modes and functionality of Ecto-Nucleoside Triphosphate Diphosphohydrolases
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DOI: 10.1038/s41598-018-20971-4
Abstract: Ecto-nucleotidase enzymes catalyze the hydrolysis of extracellular nucleotides to their respective nucleosides. Herein, we place the focus on the elucidation of structural features of the cell surface located ecto-nucleoside triphosphate diphosphohydrolases (E-NTPDase1-3 and 8). The… read more here.
Keywords: inhibitor; nucleoside triphosphate; triphosphate diphosphohydrolases; molecular dynamic ... See more keywords
Nucleoside Triphosphate Diphosphohydrolase 1 Exhibits Enzymatic Activity toward Tenofovir Diphosphate
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DOI: 10.1124/dmd.122.000855
Abstract: Tenofovir (TFV; prescribed as TFV disoproxil fumarate and TFV alafenamide prodrugs) is currently used for HIV prevention and treatment. TFV must be phosphorylated twice into TFV-diphosphate (TFV-DP) to become pharmacologically active. Previously, we reported heterogeneity… read more here.
Keywords: dephosphorylation; ntpdase; tfv; colorectal tissue ... See more keywords