Electrochemical Site-Specific Dehydrogenative Hydroxyalkylation of Purine Nucleosides with Alcohols.
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DOI: 10.1021/acs.orglett.5c02801
Abstract: An electrochemical protocol for C6-selective hydroxyalkylation of purine nucleosides with alcohols via direct C(sp2)-C(sp3) cross-coupling was established. The protocol employed N-Hydroxyphthalimide (NHPI) as a hydrogen atom transfer mediator, yielding C6-hydroxyalkyl purine nucleosides in moderate to… read more here.
Keywords: purine; electrochemical site; hydroxyalkylation purine; nucleosides alcohols ... See more keywords