Simultaneous Quantification of Nucleosides and Nucleotides from Biological Samples
Sign Up to like & getrecommendations! Published in 2019 at "Journal of The American Society for Mass Spectrometry"
DOI: 10.1007/s13361-019-02140-7
Abstract: AbstractWe report a reverse phase chromatography mass spectrometry (LC-MS) method for simultaneous quantification of nucleosides and nucleotides from biological samples, where compound identification was achieved by a tier-wise approach and compound quantification was achieved via… read more here.
Keywords: quantification nucleosides; nucleotides biological; biological samples; simultaneous quantification ... See more keywords
A simultaneously quantitative method to profiling twenty endogenous nucleosides and nucleotides in cancer cells using UHPLC-MS/MS.
Sign Up to like & getrecommendations! Published in 2018 at "Talanta"
DOI: 10.1016/j.talanta.2017.11.054
Abstract: Endogenous nucleosides and nucleotides in biosamples are frequently highlighted as the most differential metabolites in recent metabolomics studies. We developed a rapid, sensitive, high-throughput and reliable quantitative method to simultaneously profile 20 endogenous nucleosides and… read more here.
Keywords: method; nucleosides nucleotides; endogenous nucleosides; cancer cell ... See more keywords
4'-Fluoro-nucleosides and nucleotides: from nucleocidin to an emerging class of therapeutics.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Society reviews"
DOI: 10.1039/d2cs00762b
Abstract: The history and development of 4'-fluoro-nucleosides is discussed in this review. This is a class of nucleosides which have their origin in the discovery of the rare fluorine containing natural product nucleocidin. Nucleocidin contains a… read more here.
Keywords: nucleocidin emerging; fluoro nucleosides; class; nucleosides nucleotides ... See more keywords
A review on the nucleic acid constituents in mushrooms: nucleobases, nucleosides and nucleotides
Sign Up to like & getrecommendations! Published in 2018 at "Critical Reviews in Biotechnology"
DOI: 10.1080/07388551.2017.1399102
Abstract: Abstract Mushrooms have become increasingly important as a reliable food source. They have also been recognized as an important source of bioactive compounds of high nutritional and medicinal values. The nucleobases, nucleosides and nucleotides found… read more here.
Keywords: acid constituents; review nucleic; nucleobases nucleosides; nucleosides nucleotides ... See more keywords
Extracellular nucleosides and nucleotides as immunomodulators
Sign Up to like & getrecommendations! Published in 2017 at "Immunological Reviews"
DOI: 10.1111/imr.12571
Abstract: Some anticancer agents induce immunogenic cell death that is accompanied by the emission of danger signals into the tumor microenvironment, thus attracting and activating innate immune effectors and finally inducing anticancer immunity. The release of… read more here.
Keywords: nucleosides nucleotides; nucleotides immunomodulators; extracellular nucleosides; anticancer ... See more keywords
Metabolism of Nucleosides and Nucleotides Prodrugs.
Sign Up to like & getrecommendations! Published in 2017 at "Current pharmaceutical design"
DOI: 10.2174/1381612823666171011104158
Abstract: BACKGROUND Modified nucleoside and nucleotide analogs are now the cornerstone of antiviral and anticancer chemotherapies. However, these compounds are not active on their own and need, after entering the cell, to be metabolized to their… read more here.
Keywords: nucleosides nucleotides; nucleotides prodrugs; nucleoside nucleotide; metabolism nucleosides ... See more keywords
Modified Nucleosides, Nucleotides and Nucleic Acids via Click Azide-Alkyne Cycloaddition for Pharmacological Applications
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26113100
Abstract: The click azide = alkyne 1,3-dipolar cycloaddition (click chemistry) has become the approach of choice for bioconjugations in medicinal chemistry, providing facile reaction conditions amenable to both small and biological molecules. Many nucleoside analogs are… read more here.
Keywords: nucleic acids; chemistry; azide alkyne; nucleotides nucleic ... See more keywords
Tellurium-Modified Nucleosides, Nucleotides, and Nucleic Acids with Potential Applications
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27238379
Abstract: Tellurium was successfully incorporated into proteins and applied to protein structure determination through X-ray crystallography. However, studies on tellurium modification of DNA and RNA are limited. This review highlights the recent development of Te-modified nucleosides,… read more here.
Keywords: nucleotides nucleic; tellurium; potential applications; nucleosides nucleotides ... See more keywords
Mechanochemistry of nucleosides, nucleotides and related materials
Sign Up to like & getrecommendations! Published in 2018 at "Beilstein Journal of Organic Chemistry"
DOI: 10.3762/bjoc.14.81
Abstract: The application of mechanical force to induce the formation and cleavage of covalent bonds is a rapidly developing field within organic chemistry which has particular value in reducing or eliminating solvent usage, enhancing reaction rates… read more here.
Keywords: chemistry; related materials; nucleotides related; mechanochemistry nucleosides ... See more keywords