Characterization of Caenorhabditis elegans Nucleosome Assembly Protein 1 Uncovers the Role of Acidic Tails in Histone Binding.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry"
DOI: 10.1021/acs.biochem.8b01033
Abstract: Nucleosome assembly proteins (Naps) influence chromatin dynamics by directly binding to histones. Here we provide a comprehensive structural and biochemical analysis of a Nap protein from Caenorhabditis elegans (CeNap1). CeNap1 naturally lacks the acidic N-terminal… read more here.
Keywords: histone binding; uncovers role; h2a h2b; caenorhabditis elegans ... See more keywords
Enhanced nucleosome assembly at CpG sites containing an extended 5-methylcytosine analogue
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac444
Abstract: Abstract Methylation of cytosine to 5-methylcytosine (mC) at CpG sites is a prevalent reversible epigenetic mark in vertebrates established by DNA methyltransferases (MTases); the attached methyl groups can alter local structure of DNA and chromatin… read more here.
Keywords: cpg sites; dna; nucleosome assembly; methylcytosine ... See more keywords
AtMCM10 promotes DNA replication-coupled nucleosome assembly in Arabidopsis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of integrative plant biology"
DOI: 10.1111/jipb.13438
Abstract: Minichromosome Maintenance protein 10 (MCM10) is essential for DNA replication initiation and DNA elongation in yeasts and animals. Although the functions of MCM10 in DNA replication and repair have been well documented, the detail mechanisms… read more here.
Keywords: atmcm10; replication; replication coupled; nucleosome assembly ... See more keywords
RPA binds histone H3-H4 and functions in DNA replication–coupled nucleosome assembly
Sign Up to like & getrecommendations! Published in 2017 at "Science"
DOI: 10.1126/science.aah4712
Abstract: The platform for building new chromatin Nucleosomes removed from DNA to facilitate its replication must be replaced quickly to protect the genome. The epigenetic information stored on the parental nucleosomes must also be preserved on… read more here.
Keywords: dna replication; stranded dna; replication coupled; nucleosome assembly ... See more keywords
Nucleosome assembly and disassembly pathways in vitro
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0267382
Abstract: Structural fluctuations of nucleosomes modulate the access to internal DNA in eukaryotic cells; clearly characterisation of this fundamental process is crucial to understanding gene regulation. Here we apply PhAST (Photochemical Analysis of Structural Transitions) to… read more here.
Keywords: disassembly pathways; dna; assembly disassembly; nucleosome assembly ... See more keywords
Nucleosome assembly protein 1-like 5 alleviates Alzheimer’s disease-like pathological characteristics in a cell model
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.1034766
Abstract: Alzheimer’s disease (AD) remains one of the most common dementias of neurodegenerative disease-related diseases. Nucleosome assembly protein 1-like 5 (NAP1L5) belongs to the NAP1L protein family, which acts as a histone chaperone. However, the function… read more here.
Keywords: cell model; disease; alzheimer disease; assembly protein ... See more keywords
Nucleosome Assembly Protein 1, Nap1, Is Required for the Growth, Development, and Pathogenicity of Magnaporthe oryzae
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23147662
Abstract: Magnaporthe oryzae is the causal agent of rice blast, leading to significant reductions in rice and wheat productivity. Nap1 is a conserved protein in eukaryotes involved in diverse physiological processes, such as nucleosome assembly, histone… read more here.
Keywords: growth; development; assembly protein; pathogenicity ... See more keywords
The Role of Histone Modification in DNA Replication-Coupled Nucleosome Assembly and Cancer
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24054939
Abstract: Histone modification regulates replication-coupled nucleosome assembly, DNA damage repair, and gene transcription. Changes or mutations in factors involved in nucleosome assembly are closely related to the development and pathogenesis of cancer and other human diseases… read more here.
Keywords: replication coupled; histone modification; nucleosome assembly; modification ... See more keywords