Nucleosome Core Particles Lacking H2B or H3 Tails Are Altered Structurally and Have Differential Base Excision Repair Fingerprints.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemistry"
DOI: 10.1021/acs.biochem.0c00877
Abstract: A recently discovered post-translational modification of histone proteins is the irreversible proteolytic clipping of the histone N-terminal tail domains. This modification is involved in the regulation of various biological processes, including the DNA damage response.… read more here.
Keywords: excision; h2b; tail; nucleosome core ... See more keywords
Effect of Histone Lysine Methylation on DNA Lesion Reactivity in Nucleosome Core Particles.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.9b00049
Abstract: Lysine methylation is a common post-translational histone modification that regulates transcription and gene expression. The lysine residues in the histone tail also react with damaged nucleotides in chromatin, including abasic sites and N7-methyl-2'-deoxyguanosine, the major… read more here.
Keywords: methylation; lysine methylation; core particles; dna ... See more keywords
Correlating histone acetylation with nucleosome core particle dynamics and function.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2301063120
Abstract: Epigenetic modifications of chromatin play a critical role in regulating the fidelity of the genetic code and in controlling the translation of genetic information into the protein components of the cell. One key posttranslational modification… read more here.
Keywords: acetylation; core particle; histone; nucleosome core ... See more keywords
Cryo-EM structure of the nucleosome core particle containing Giardia lamblia histones
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab644
Abstract: Abstract Giardia lamblia is a pathogenic unicellular eukaryotic parasite that causes giardiasis. Its genome encodes the canonical histones H2A, H2B, H3, and H4, which share low amino acid sequence identity with their human orthologues. We… read more here.
Keywords: core particle; lamblia histones; lamblia; giardia lamblia ... See more keywords
Unencumbered Pol β lyase activity in nucleosome core particles
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx593
Abstract: Abstract Packaging of DNA into the nucleosome core particle (NCP) is considered to exert constraints to all DNA-templated processes, including base excision repair where Pol β catalyzes two key enzymatic steps: 5′-dRP lyase gap trimming… read more here.
Keywords: unencumbered pol; pol lyase; nucleosome core; dna ... See more keywords