Evaluation of genetic variants in nucleosome remodeling and deacetylase (NuRD) complex subunits encoding genes and gastric cancer susceptibility.
Sign Up to like & getrecommendations! Published in 2022 at "Archives of toxicology"
DOI: 10.1007/s00204-022-03275-5
Abstract: Epigenetic complex NuRD (nucleosome remodeling and deacetylase) engages in a range of basic cellular processes, including chromatin modification. Changes in the activity of NuRD complex can influence gastric cancer progression. Multivariate logistic regression analyses were… read more here.
Keywords: cancer; expression; remodeling deacetylase; nucleosome remodeling ... See more keywords
The Methyl-CpG Binding Domain 2 and 3 proteins and formation of the Nucleosome Remodeling and Deacetylase complex.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2019.10.007
Abstract: The Nucleosome Remodeling and Deacetylase (NuRD) complex uniquely combines both deacetylase and remodeling enzymatic activities in a single macromolecular complex. The Methyl-CpG Binding Domain 2 and 3 (MBD2 and MBD3) proteins provide a critical structural… read more here.
Keywords: deacetylase; binding domain; remodeling deacetylase; methyl cpg ... See more keywords
The Nucleosome Remodeling and Deacetylation Complex Modulates Chromatin Structure at Sites of Active Transcription to Fine-Tune Gene Expression
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cell"
DOI: 10.1016/j.molcel.2018.06.003
Abstract: Summary Chromatin remodeling complexes play essential roles in metazoan development through widespread control of gene expression, but the precise molecular mechanisms by which they do this in vivo remain ill defined. Using an inducible system… read more here.
Keywords: deacetylation; transcription; nucleosome remodeling; gene expression ... See more keywords
Acidic patch histone mutations and their effects on nucleosome remodeling.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Society transactions"
DOI: 10.1042/bst20210773
Abstract: Structural and biochemical studies have identified a histone surface on each side of the nucleosome disk termed 'the nucleosome acidic patch' that acts as a regulatory hub for the function of numerous nuclear proteins, including… read more here.
Keywords: nucleosome remodeling; patch histone; histone mutations; acidic patch ... See more keywords
NAP1L1 accelerates activation and decreases pausing to enhance nucleosome remodeling by CSB
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx188
Abstract: Abstract Cockayne syndrome protein B (CSB) belongs to the SWI2/SNF2 ATP-dependent chromatin remodeler family, and CSB is the only ATP-dependent chromatin remodeler essential for transcription-coupled nucleotide excision DNA repair. CSB alone remodels nucleosomes ∼10-fold slower… read more here.
Keywords: chromatin remodeling; nucleosome remodeling; remodeling csb; activation ... See more keywords