Nucleotide Analogues as Inhibitors of SARS-CoV-2 Polymerase, a Key Drug Target for COVID-19
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Proteome Research"
DOI: 10.1021/acs.jproteome.0c00392
Abstract: SARS-CoV-2 is responsible for the current COVID-19 pandemic. On the basis of our analysis of hepatitis C virus and coronavirus replication, and the molecular structures and activities of viral inhibitors, we previously demonstrated that three… read more here.
Keywords: nucleotide analogues; drug target; cov rdrp; target covid ... See more keywords
Synthesis of Nucleoside and Nucleotide Analogues by Cyclization of the Guanine Base with 1,1,3,3-Tetramethoxypropane.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c03252
Abstract: 3-(2-Deoxy-β-d-erythropentofuranosyl)pyrimido[1,2-a]purin-10(3H)-one (M1dG) is an endogenous DNA adduct in bacterial and mammalian cells that could be explored as a biomarker for oxidative stress. Nonetheless, the lack of an efficient methodology for the preparation of M1dG hampers… read more here.
Keywords: analogues cyclization; guanine base; nucleoside nucleotide; nucleotide analogues ... See more keywords
Penetration of Antitumor Nucleotide–Actinomycin Nanocomplexes into Thymocytes
Sign Up to like & getrecommendations! Published in 2019 at "Nanotechnologies in Russia"
DOI: 10.1134/s1995078019060053
Abstract: Abstract—Spectrophotometry, spectrofluorimetry, IR spectroscopy, quasi-dark-field and fluorescence microscopy were used to investigate the conditions for penetration of the heterocyclic antitumor antibiotic actinomycin D (AMD) and its fluorescent derivative 7-amino-actinomycin D (7AAMD) into T cells (thymocytes)… read more here.
Keywords: actinomycin; amd 7aamd; penetration antitumor; nucleotide analogues ... See more keywords