What monomeric nucleotide binding domains can teach us about dimeric ABC proteins
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Letters"
DOI: 10.1002/1873-3468.13921
Abstract: The classic conceptualization of ATP binding cassette (ABC) transporter function is an ATP‐dependent conformational change coupled to transport of a substrate across a biological membrane via the transmembrane domains (TMDs). The binding of two ATP… read more here.
Keywords: nbd dimerization; nucleotide binding; binding domains; abc proteins ... See more keywords
Harnessing the untapped potential of nucleotide‐binding oligomerization domain ligands for cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2018 at "Medicinal Research Reviews"
DOI: 10.1002/med.21557
Abstract: In the last decade, cancer immunotherapy has emerged as an effective alternative to traditional therapies such as chemotherapy and radiation. In contrast to the latter, cancer immunotherapy has the potential to distinguish between cancer and… read more here.
Keywords: cancer; binding oligomerization; cancer immunotherapy; nucleotide binding ... See more keywords
Information theoretic measures and mutagenesis identify a novel linchpin residue involved in substrate selection within the nucleotide-binding domain of an ABCG family exporter Cdr1p.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2019.01.013
Abstract: ABC transporters are membrane-bound pumps composed of two major domains: the transmembrane domain(s) (TMDs) and the nucleotide-binding domain(s) (NBDs). Sequence analyses of the NBDs of key ABC exporters revealed a residue position within the H-loop… read more here.
Keywords: abcg family; binding domain; nucleotide binding; family ... See more keywords
Expression and localization of guanine nucleotide-binding protein alpha S in the testis and epididymis of rams at different developmental stages.
Sign Up to like & getrecommendations! Published in 2017 at "Animal reproduction science"
DOI: 10.1016/j.anireprosci.2017.01.006
Abstract: The guanine nucleotide-binding alpha S subunit (Gαs) is an important element of key signaling pathways, which is widely expressed in mammalian tissues; however, its role in the reproductive system is still unclear. In this study,… read more here.
Keywords: different developmental; guanine nucleotide; rams different; nucleotide binding ... See more keywords
Altered cyclic nucleotide-binding and pore opening in a diseased human HCN4 channel.
Sign Up to like & getrecommendations! Published in 2022 at "Biophysical journal"
DOI: 10.1016/j.bpj.2022.02.035
Abstract: A growing number of nonsynonymous mutations in the human HCN4 channel gene, the major component of the funny channel of the sinoatrial node, are associated with disease but how they impact channel structure and function,… read more here.
Keywords: channel; nucleotide binding; cyclic nucleotide; human hcn4 ... See more keywords
Molecular cloning and functional characterization of duck nucleotide‐binding oligomerization domain 1 (NOD1)
Sign Up to like & getrecommendations! Published in 2017 at "Developmental and Comparative Immunology"
DOI: 10.1016/j.dci.2017.04.012
Abstract: &NA; Nucleotide‐binding oligomerization domain 1 (NOD1) is an imperative cytoplasmic pattern recognition receptor (PRR) and considered as a key member of the NOD‐like receptor (NLR) family which plays a critical role in innate immunity through… read more here.
Keywords: nucleotide binding; binding oligomerization; duck; oligomerization domain ... See more keywords
Genome-wide identification and tissue-specific expression analysis of nucleotide binding site-leucine rich repeat gene family in Cicer arietinum (kabuli chickpea)
Sign Up to like & getrecommendations! Published in 2017 at "Genomics Data"
DOI: 10.1016/j.gdata.2017.08.004
Abstract: The nucleotide binding site-leucine rich repeat (NBS-LRR) proteins play an important role in the defense mechanisms against pathogens. Using bioinformatics approach, we identified and annotated 104 NBS-LRR genes in chickpea. Phylogenetic analysis points to their… read more here.
Keywords: nucleotide binding; analysis; binding site; nbs lrr ... See more keywords
The E-helix is a central core in a conserved helical bundle involved in nucleotide binding and transmembrane domain intercalation in the ABC transporter superfamily.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.01.030
Abstract: ABC transporter proteins are involved in active transport, both in prokaryotes and eukaryotes. Sequence analysis of nucleotide binding domains (NBDs) of ABC proteins from all taxa revealed a well-conserved new motif having the signature: xT/ShxE/DNhxF,… read more here.
Keywords: nucleotide binding; abc transporter; domain; helix central ... See more keywords
Biochemical and biophysical characterization of nucleotide binding domain of Trehalose transporter from Mycobacterium tuberculosis.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.02.237
Abstract: The SugABC is an ABC transporter in Mycobacterium tuberculosis which is proposed to be involved in the process of Trehalose import, but till date the proteins of this transporter complex have not been functionally characterized.… read more here.
Keywords: nucleotide binding; transporter; transporter mycobacterium; domain ... See more keywords
Activation of nucleotide-binding oligomerization domain-containing protein 1 by diaminopimelic acid contributes to cerebral ischemia-induced cognitive impairment
Sign Up to like & getrecommendations! Published in 2021 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2020.135547
Abstract: Cerebral ischemia-reperfusion (I/R)-induced brain tissue injury is a major obstacle for acute stroke management. Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) is reported to play a critical role in the regulation of myocardial or hepatic I/R… read more here.
Keywords: nucleotide binding; cerebral ischemia; binding oligomerization; oligomerization domain ... See more keywords
Genome-wide identification, characterization, and expression analysis of nucleotide-binding leucine-rich repeats gene family under environmental stresses in tea (Camellia sinensis).
Sign Up to like & getrecommendations! Published in 2019 at "Genomics"
DOI: 10.1016/j.ygeno.2019.08.004
Abstract: Plants often use nucleotide-binding leucine-rich repeats (NLRs) to recognize specific virulence proteins and activate the hypersensitive response thereby defending against invaders. However, data on NLRs and the resistance mechanism of NLR protein mediation in tea… read more here.
Keywords: sinensis; leucine rich; nucleotide binding; analysis ... See more keywords