The synergy between nucleotide biosynthesis inhibitors and antiviral nucleosides: New opportunities against viral infections?
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200217
Abstract: 5'-Phosphorylated nucleoside derivatives are molecules that can be found in all living organisms and viruses. Over the last century, the development of structural analogs that could disrupt the transcription and translation of genetic information culminated… read more here.
Keywords: inhibitors antiviral; nucleotide biosynthesis; biosynthesis inhibitors; antiviral nucleosides ... See more keywords
Human pyrimidine nucleotide biosynthesis as a target for antiviral chemotherapy.
Sign Up to like & getrecommendations! Published in 2017 at "Current opinion in biotechnology"
DOI: 10.1016/j.copbio.2017.03.010
Abstract: The development of broad-spectrum, host-acting antiviral therapies remains an important but elusive goal in anti-infective drug discovery. To replicate efficiently, viruses not only depend on their hosts for an adequate supply of pyrimidine nucleotides, but… read more here.
Keywords: pyrimidine nucleotide; human pyrimidine; nucleotide biosynthesis; biosynthesis target ... See more keywords
Rapid Inhibition Profiling Identifies a Keystone Target in the Nucleotide Biosynthesis Pathway.
Sign Up to like & getrecommendations! Published in 2018 at "ACS chemical biology"
DOI: 10.1021/acschembio.8b00273
Abstract: Understanding the mechanism of action (MOA) of new antimicrobial agents is a critical step in drug discovery but is notoriously difficult for compounds that appear to inhibit multiple cellular pathways. We recently described image-based approaches… read more here.
Keywords: biosynthesis; biosynthesis pathway; nucleotide biosynthesis; dna replication ... See more keywords
Liver nucleotide biosynthesis is linked to protection from vascular complications in individuals with long-term type 1 diabetes
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-68130-y
Abstract: Identification of biomarkers associated with protection from developing diabetic complications is a prerequisite for an effective prevention and treatment. The aim of the present study was to identify clinical and plasma metabolite markers associated with… read more here.
Keywords: protection; nucleotide biosynthesis; type diabetes; protection vascular ... See more keywords
Horizontal transfer of a pathway for coumarate catabolism unexpectedly inhibits purine nucleotide biosynthesis
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Microbiology"
DOI: 10.1111/mmi.14393
Abstract: A microbe’s ecological niche and biotechnological utility are determined by its specific set of co‐evolved metabolic pathways. The acquisition of new pathways, through horizontal gene transfer or genetic engineering, can have unpredictable consequences. Here we… read more here.
Keywords: catabolism; purine nucleotide; coumarate catabolism; nucleotide biosynthesis ... See more keywords