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Published in 2020 at "Clinical Pharmacokinetics"
DOI: 10.1007/s40262-020-00934-7
Abstract: Pyrimidine analogues can be considered as prodrugs, like their natural counterparts, they have to be activated within the cell. The intracellular activation involves several metabolic steps including sequential phosphorylation to its monophosphate, diphosphate and triphosphate.…
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Keywords:
pyrimidine analogues;
nucleotide concentrations;
intracellular nucleotide;
oncology ... See more keywords