Hydrolysis of the non-canonical cyclic nucleotide cUMP by PDE9A: kinetics and binding mode
Sign Up to like & getrecommendations! Published in 2018 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-018-1582-5
Abstract: The non-canonical cyclic nucleotide cUMP and the phosphodiesterase PDE9A both occur in neuronal cells. Using HPLC-coupled tandem mass spectrometry, we characterized the kinetics of PDE9A-mediated cUMP hydrolysis. PDE9A is a low-affinity and high-velocity enzyme for… read more here.
Keywords: pde9a; cyclic nucleotide; canonical cyclic; non canonical ... See more keywords