Major Roles for Pyrimidine Dimers, Nucleotide Excision Repair, and ATR in the Alternative Splicing Response to UV Irradiation.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.02.066
Abstract: We have previously found that UV irradiation promotes RNA polymerase II (RNAPII) hyperphosphorylation and subsequent changes in alternative splicing (AS). We show now that UV-induced DNA damage is not only necessary but sufficient to trigger… read more here.
Keywords: nucleotide excision; response; excision repair; pyrimidine dimers ... See more keywords
Third EU-US workshop on "Nucleotide excision repair and crosslink repair-From molecules to mankind", Smolenice Castle, Slovak Republic, May 7th-11th 2017
Sign Up to like & getrecommendations! Published in 2017 at "DNA Repair"
DOI: 10.1016/j.dnarep.2017.08.009
Abstract: Abstract The purpose of this workshop was to bring together scientists from the EU and US to discuss our current understanding of how protein machines assemble and sort through genomic DNA to identify specific damaged… read more here.
Keywords: workshop; nucleotide excision; excision repair; molecules mankind ... See more keywords
NuA4 acetyltransferase is required for efficient nucleotide excision repair in yeast.
Sign Up to like & getrecommendations! Published in 2019 at "DNA repair"
DOI: 10.1016/j.dnarep.2018.11.006
Abstract: The nucleotide excision repair (NER) pathway is critical for removing damage induced by ultraviolet (UV) light and other helix-distorting lesions from cellular DNA. While efficient NER is critical to avoid cell death and mutagenesis, NER… read more here.
Keywords: nucleotide excision; acetyltransferase; required efficient; excision repair ... See more keywords
Histone deacetylation regulates nucleotide excision repair through an interaction with the XPC protein
Sign Up to like & getrecommendations! Published in 2022 at "iScience"
DOI: 10.1016/j.isci.2022.104040
Abstract: Summary The XPC protein complex plays a central role in DNA lesion recognition for global genome nucleotide excision repair (GG-NER). Lesion recognition can be accomplished in either a UV-DDB-dependent or -independent manner; however, it is… read more here.
Keywords: xpc protein; nucleotide excision; histone deacetylation; xpc ... See more keywords
Inhibition of nucleotide excision repair and damage response signaling by dibromoacetonitrile: A novel genotoxicity mechanism of a water disinfection byproduct
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Hazardous Materials"
DOI: 10.1016/j.jhazmat.2021.127194
Abstract: Abstract Dibromoacetonitrile (DBAN) is a carcinogenic disinfection byproduct (DBP) but how it precipitates cancer is unknown. Nucleotide excision repair (NER) is a versatile repair mechanism for removing bulky DNA lesions to maintain genome stability, and… read more here.
Keywords: nucleotide excision; mechanism; excision repair; damage ... See more keywords
Inhibition of Excison of Oxidatively Generated Hydantoin DNA Lesions by NEIL1 by the Competitive Binding of the Nucleotide Excision Repair Factor XPC-RAD23B.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemistry"
DOI: 10.1021/acs.biochem.0c00080
Abstract: The interplay between nucleotide excision repair (NER) and base excision repair (BER) of non-bulky, oxidatively generated DNA lesion, has long been a subject of significant interest. The hydantoin oxidation products of 8-oxoguanine, spiroiminodihydantoin (Sp) and… read more here.
Keywords: xpc; factor; nucleotide excision; excision repair ... See more keywords
α,β-Unsaturated Aldehyde-Induced Delays in Nucleotide Excision Repair and the Contribution of Reactive Oxygen Species.
Sign Up to like & getrecommendations! Published in 2018 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.7b00304
Abstract: Aldehydes are widespread environmental and industrial compounds to which humans are frequently exposed. Despite their significant health risk, the mechanisms underlying aldehyde toxicity are poorly understand. We recently demonstrated that cigarette sidestream smoke (CSS) inhibited… read more here.
Keywords: unsaturated aldehydes; reactive oxygen; nucleotide excision; oxygen species ... See more keywords
Single-molecule live-cell imaging visualizes parallel pathways of prokaryotic nucleotide excision repair
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-15179-y
Abstract: In the model organism Escherichia coli , helix distorting lesions are recognized by the UvrAB damage surveillance complex in the global genomic nucleotide excision repair pathway (GGR). Alternately, during transcription-coupled repair (TCR), UvrA is recruited… read more here.
Keywords: excision repair; single molecule; nucleotide excision; repair ... See more keywords
Identification of the target and mode of action for the prokaryotic nucleotide excision repair inhibitor ATBC
Sign Up to like & getrecommendations! Published in 2022 at "Bioscience Reports"
DOI: 10.1042/bsr20220403
Abstract: Abstract In bacteria, nucleotide excision repair (NER) plays a major role in repairing DNA damage from a wide variety of sources. Therefore, its inhibition offers potential to develop a new antibacterial in combination with adjuvants,… read more here.
Keywords: excision repair; nucleotide excision; action; inhibitor ... See more keywords
Mechanism of action of nucleotide excision repair machinery.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Society transactions"
DOI: 10.1042/bst20210246
Abstract: Nucleotide excision repair (NER) is a versatile DNA repair pathway essential for the removal of a broad spectrum of structurally diverse DNA lesions arising from a variety of sources, including UV irradiation and environmental toxins.… read more here.
Keywords: excision repair; mechanism action; machinery; nucleotide excision ... See more keywords
A disease-associated XPA allele interferes with TFIIH binding and primarily affects transcription-coupled nucleotide excision repair
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2208860120
Abstract: Significance Nucleotide excision DNA repair (NER) removes a large variety of genomic lesions. NER can be initiated through two distinct pathways: global genome repair (GG-NER) and transcription-coupled repair (TC-NER). Both pathways subsequently funnel into a… read more here.
Keywords: xpa; transcription; nucleotide excision; transcription coupled ... See more keywords