Structural and functional remodeling of the atrioventricular node with aging in rats: The role of hyperpolarization-activated cyclic nucleotide–gated and ryanodine 2 channels
Sign Up to like & getrecommendations! Published in 2018 at "Heart Rhythm"
DOI: 10.1016/j.hrthm.2017.12.027
Abstract: Background Aging is associated with an increased incidence of atrioventricular nodal (AVN) dysfunction. Objective The aim of this study was to investigate the structural and functional remodeling in the atrioventricular junction (AVJ) with aging. Methods… read more here.
Keywords: cyclic nucleotide; activated cyclic; nucleotide gated; hyperpolarization activated ... See more keywords
Structural basis of calmodulin modulation of the rod cyclic nucleotide-gated channel.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2300309120
Abstract: Calmodulin (CaM) regulates many ion channels to control calcium entry into cells, and mutations that alter this interaction are linked to fatal diseases. The structural basis of CaM regulation remains largely unexplored. In retinal photoreceptors,… read more here.
Keywords: structural basis; cam; cyclic nucleotide; nucleotide gated ... See more keywords
The hyperpolarization‐activated cyclic nucleotide‐gated 4 channel as a potential anti‐seizure drug target
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15088
Abstract: Hyperpolarization‐activated cyclic nucleotide‐gated (HCN) channels are encoded by four genes (HCN1–4) with distinct biophysical properties and functions within the brain. HCN4 channels activate slowly at robust hyperpolarizing potentials, making them more likely to be engaged… read more here.
Keywords: cyclic nucleotide; activated cyclic; nucleotide gated; hyperpolarization activated ... See more keywords
Liraglutide increases islet Ca2+ oscillation frequency and insulin secretion by activating hyperpolarization‐activated cyclic nucleotide‐gated channels
Sign Up to like & getrecommendations! Published in 2022 at "Diabetes"
DOI: 10.1111/dom.14747
Abstract: To determine whether hyperpolarization‐activated cyclic nucleotide‐gated (HCN) channels impact glucagon‐like peptide‐1 (GLP‐1) receptor (GLP‐1R) modulation of islet Ca2+ handling and insulin secretion. read more here.
Keywords: activated cyclic; insulin secretion; hyperpolarization activated; cyclic nucleotide ... See more keywords
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels as Drug Targets for Neurological Disorders.
Sign Up to like & getrecommendations! Published in 2020 at "Annual review of pharmacology and toxicology"
DOI: 10.1146/annurev-pharmtox-010919-023356
Abstract: The hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are voltage-gated ion channels that critically modulate neuronal activity. Four HCN subunits (HCN1-4) have been cloned, each having a unique expression profile and distinctive effects on neuronal excitability within… read more here.
Keywords: cyclic nucleotide; activated cyclic; nucleotide gated; hyperpolarization activated ... See more keywords
CNGCs break through—A rice cyclic nucleotide-gated channel paves the way for pollen tube growth
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1007066
Abstract: Lower plants generate mobile sperm cells that must reach their female counterparts by swimming. This requirement for water is a disadvantage for these plants as compared with angiosperms, for which the dry pollen attaches to… read more here.
Keywords: tube; cyclic nucleotide; nucleotide gated; growth ... See more keywords
Direct Regulation of Hyperpolarization-Activated Cyclic-Nucleotide Gated (HCN1) Channels by Cannabinoids
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.848540
Abstract: Cannabinoids are a broad class of molecules that act primarily on neurons, affecting pain sensation, appetite, mood, learning, and memory. In addition to interacting with specific cannabinoid receptors (CBRs), cannabinoids can directly modulate the function… read more here.
Keywords: hcn1; activated cyclic; hcn1 channels; hyperpolarization activated ... See more keywords
Cyclic Nucleotide-Gated Ion Channel 6 Mediates Thermotolerance in Arabidopsis Seedlings by Regulating Hydrogen Peroxide Production via Cytosolic Calcium Ions
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2021.708672
Abstract: We previously reported the involvement of cyclic nucleotide-gated ion channel 6 (CNGC6) and hydrogen peroxide (H2O2) in plant responses to heat shock (HS). To demonstrate their relationship with plant thermotolerance, we assessed the effect of… read more here.
Keywords: cyclic nucleotide; gated ion; nucleotide gated; h2o2 ... See more keywords
Retinal Cyclic Nucleotide-Gated Channel Regulation by Calmodulin
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232214143
Abstract: Retinal cyclic nucleotide-gated (CNG) ion channels bind to intracellular cGMP and mediate visual phototransduction in photoreceptor rod and cone cells. Retinal rod CNG channels form hetero-tetramers comprised of three CNGA1 and one CNGB1 protein subunits.… read more here.
Keywords: retinal cyclic; cng channels; cyclic nucleotide; channel ... See more keywords
Genome-Wide Analysis of Cyclic Nucleotide-Gated Channel Genes Related to Pollen Development in Rice
Sign Up to like & getrecommendations! Published in 2022 at "Plants"
DOI: 10.3390/plants11223145
Abstract: In the angiosperm, pollen germinates and rapidly expands the pollen tube toward the ovule. This process is important for plant double fertilization and seed setting. It is well known that the tip-focused calcium gradient is… read more here.
Keywords: pollen; pollen tube; rice; tube ... See more keywords